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Background <p>To characterize the duration and determinants of SFTSV-specific antibody persistence following natural infection, informing vaccine development for severe fever with thrombocytopenia syndrome (SFTS).</p> Methods <p>We conducted a retrospective cohort study among 463 convalescent SFTS patients in the Dabie Mountains, a hyperendemic region in China. Using illness onset dates and a single post-infection serum sample per participant, we reconstructed individual follow-up durations and applied Kaplan–Meier survival analysis and Cox proportional hazards models to assess time to seroreversion and its determinants.</p> Results <p>Seropositivity declined with longer time since illness onset. Age was significantly associated with antibody persistence: individuals aged ≥ 70 years showed the most rapid antibody waning, whereas those aged &lt; 50 years showed longer detectable IgG persistence. Geographic location was also associated with durability. Compared with patients from Huoqiu County (predominantly plain terrain), those from mountainous/hilly areas had lower risks of antibody loss—Yu’an District (HR 0.060 [95%CI 0.014–0.262]) Jinzhai County(HR 0.358 [95%CI 0.202–0.635]) and Huoshan County(HR 0.390 [95%CI 0.195–0.780]).</p> Conclusion <p>SFTSV-specific IgG antibodies persist for several years in most survivors, with longer duration observed in younger individuals and residents of highland endemic foci. These findings suggest that of age and geography in shaping post-infection immunity and support tailored vaccination and surveillance strategies in heterogeneous transmission settings.</p> Clinical trial number <p>Not applicable.</p>

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A study on antibody persistence following severe fever with thrombocytopenia syndrome virus infection in the Dabie Mountain Region, China

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月27日

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  • Jie Sun,
  • Jianguo Rao,
  • Pengpeng Xu,
  • Wei Yang,
  • Mingyang Yang,
  • Weigang Zhang,
  • Zhuo Wang,
  • Xianjun Lin,
  • Limin Wang,
  • Yong Lyu

摘要

Background

To characterize the duration and determinants of SFTSV-specific antibody persistence following natural infection, informing vaccine development for severe fever with thrombocytopenia syndrome (SFTS).

Methods

We conducted a retrospective cohort study among 463 convalescent SFTS patients in the Dabie Mountains, a hyperendemic region in China. Using illness onset dates and a single post-infection serum sample per participant, we reconstructed individual follow-up durations and applied Kaplan–Meier survival analysis and Cox proportional hazards models to assess time to seroreversion and its determinants.

Results

Seropositivity declined with longer time since illness onset. Age was significantly associated with antibody persistence: individuals aged ≥ 70 years showed the most rapid antibody waning, whereas those aged < 50 years showed longer detectable IgG persistence. Geographic location was also associated with durability. Compared with patients from Huoqiu County (predominantly plain terrain), those from mountainous/hilly areas had lower risks of antibody loss—Yu’an District (HR 0.060 [95%CI 0.014–0.262]) Jinzhai County(HR 0.358 [95%CI 0.202–0.635]) and Huoshan County(HR 0.390 [95%CI 0.195–0.780]).

Conclusion

SFTSV-specific IgG antibodies persist for several years in most survivors, with longer duration observed in younger individuals and residents of highland endemic foci. These findings suggest that of age and geography in shaping post-infection immunity and support tailored vaccination and surveillance strategies in heterogeneous transmission settings.

Clinical trial number

Not applicable.