Background <p>Blood transfusions which save lives through their essential function bring infection risks to users especially in areas with limited medical resources.</p> Objective <p>The research study aimed to determine the main factors that cause blood transfusion-transmitted infections in donated blood.</p> Methods <p>This was a cross-sectional study among voluntary blood donors. Blood tests were conducted on samples from the study to detect common transfusion-transmitted infections which included Hepatitis B (HBV) Hepatitis C (HCV) HIV Syphilis and Malaria. Data on demographic characteristics and health history information was collected using a structured questionnaire. Descriptive statistics and multivariate logistic regression were used to identify the risk factors for association with TTI.</p> Results <p>The study discovered that TTIs exist in low levels because they found Hepatitis B in 1.85% of samples and Malaria in 2.78% of samples. The study identified three main risk factors which led to transfusion infections through previous surgery (odds ratio [OR] = 2.1), multiple blood donations (OR = 1.8), and unscreened donor history (OR = 3.4). The research identified three main factors which determine blood transfusion infection risk.</p> Conclusion <p>The implementation of better donor screening processes together with educational programs and infection control strategies will effectively decrease the risk associated with transfusions.</p> Clinical trial <p>N/A.</p>