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Objective <p>Despite advances in prevention and treatment, the burden of acute viral hepatitis (AVH) remains substantial yet understudied in the elderly. In this study, we used data from the Global Burden of Disease (GBD) 2021 database to analyze burden, inequality, and trends associated with acute hepatitis from 1990 to 2021 in individuals aged 60 years and above.</p> Methods <p>Data on AVH burden in the elderly were extracted from the GBD 2021 database for analysis of age-standardized prevalence rates (ASPR), age-standardized incidence rates(ASIR), age-standardized mortality rates(ASMR), age-standardized disability-adjusted life years [DALYs] rates(ASDR) and demographic factors (gender, age group). Analytical techniques included joinpoint regression, decomposition analyses, and predictive modeling to assess temporal trends and future projections.</p> Results <p>From 1990 to 2021, trends in global age-specific prevalence, incidence, mortality, and DALY rates (ASPR, ASIR, ASMR, and ASDR, respectively) were consistently downward. Specifically, low–Social Development Index (SDI) countries exhibited higher prevalence, incidence, and mortality rates and more DALYs. Frontier analysis showed that the AVH-related ASDR from 1990 to 2021 generally decreased with increasing SDI, indicating that higher levels of social development were associated with better health outcomes in the elderly. Generally, age analysis indicated declines in prevalence and incidence with age, with a valley around 85–89 years for most SDI regions, followed by a slight rise. By 2050, ASPR and ASIR were projected to show an upward trend, while ASMR and ASDR were expected to decline.</p> Conclusions <p>This study highlighted a continuing, albeit declining, burden of AVH in the elderly, with stark regional disparities influenced by sociodemographic factors. Despite reductions in incidence and prevalence, mortality and DALYs remain high in low-SDI regions, underscoring the need for targeted interventions. These findings stress the importance of equitable healthcare strategies to address the specific needs of the elderly population worldwide and help achieve the hepatitis elimination goals of the World Health Organization.</p> Clinical trial number <p>Not applicable.</p>

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Assessing the global burden of acute viral hepatitis in the elderly: a comprehensive analysis of data from the GBD 2021 database

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月9日

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  • Tongjing Xing,
  • Hongwei Wu,
  • Ali Li,
  • Hui Shao,
  • Hangshuai Qu,
  • Jiapei Ding,
  • Xuequan Wang

摘要

Objective

Despite advances in prevention and treatment, the burden of acute viral hepatitis (AVH) remains substantial yet understudied in the elderly. In this study, we used data from the Global Burden of Disease (GBD) 2021 database to analyze burden, inequality, and trends associated with acute hepatitis from 1990 to 2021 in individuals aged 60 years and above.

Methods

Data on AVH burden in the elderly were extracted from the GBD 2021 database for analysis of age-standardized prevalence rates (ASPR), age-standardized incidence rates(ASIR), age-standardized mortality rates(ASMR), age-standardized disability-adjusted life years [DALYs] rates(ASDR) and demographic factors (gender, age group). Analytical techniques included joinpoint regression, decomposition analyses, and predictive modeling to assess temporal trends and future projections.

Results

From 1990 to 2021, trends in global age-specific prevalence, incidence, mortality, and DALY rates (ASPR, ASIR, ASMR, and ASDR, respectively) were consistently downward. Specifically, low–Social Development Index (SDI) countries exhibited higher prevalence, incidence, and mortality rates and more DALYs. Frontier analysis showed that the AVH-related ASDR from 1990 to 2021 generally decreased with increasing SDI, indicating that higher levels of social development were associated with better health outcomes in the elderly. Generally, age analysis indicated declines in prevalence and incidence with age, with a valley around 85–89 years for most SDI regions, followed by a slight rise. By 2050, ASPR and ASIR were projected to show an upward trend, while ASMR and ASDR were expected to decline.

Conclusions

This study highlighted a continuing, albeit declining, burden of AVH in the elderly, with stark regional disparities influenced by sociodemographic factors. Despite reductions in incidence and prevalence, mortality and DALYs remain high in low-SDI regions, underscoring the need for targeted interventions. These findings stress the importance of equitable healthcare strategies to address the specific needs of the elderly population worldwide and help achieve the hepatitis elimination goals of the World Health Organization.

Clinical trial number

Not applicable.