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Background <p>We describe the catastrophic seven-year journey of a young man with drug-resistant tuberculosis (TB) in China, initially managed with empiric therapy without baseline molecular testing.</p> Case presentation <p>He relapsed with rifampicin-resistant TB, complicated by empyema, bronchopleural fistula, and multiple failed surgeries. Management required prolonged, individualized therapy with severe toxicities, including linezolid-induced peripheral neuropathy, and staged thoracic reconstruction.</p> Interpretation <p>Although microbiological cure was achieved, the patient was left with severe post-tuberculosis lung disease and functional disability. This case highlights the consequences of omitting rapid molecular diagnostics, the essential role of multidisciplinary collaboration, and the need to extend TB care beyond microbiological cure to long-term rehabilitation. This case report is reported in accordance with the CARE guidelines.</p>

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A catastrophic seven-year course of drug-resistant tuberculosis and lessons for multidisciplinary management: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月28日

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  • Liang Fu,
  • Lin Wang,
  • Xueyong Bu,
  • Yuping Mo,
  • Yourou Zheng,
  • Guofang Deng

摘要

Background

We describe the catastrophic seven-year journey of a young man with drug-resistant tuberculosis (TB) in China, initially managed with empiric therapy without baseline molecular testing.

Case presentation

He relapsed with rifampicin-resistant TB, complicated by empyema, bronchopleural fistula, and multiple failed surgeries. Management required prolonged, individualized therapy with severe toxicities, including linezolid-induced peripheral neuropathy, and staged thoracic reconstruction.

Interpretation

Although microbiological cure was achieved, the patient was left with severe post-tuberculosis lung disease and functional disability. This case highlights the consequences of omitting rapid molecular diagnostics, the essential role of multidisciplinary collaboration, and the need to extend TB care beyond microbiological cure to long-term rehabilitation. This case report is reported in accordance with the CARE guidelines.