Scholarlink

Background <p>Tuberculosis (TB) remains a major global public health challenge, significantly impacting morbidity and mortality. Assessing the patient-reported Health-Related Quality of Life (HRQoL) is crucial for understanding the comprehensive burden of TB. This study aimed to evaluate HRQoL and its associated factors among adult TB patients in the Kembata Zone, Southern Ethiopia.</p> Methods <p>A concurrent triangulation mixed-methods study was conducted from December 1 to 30, 2023. A multi-stage sampling technique was used to select 597 participants from health facilities across the zone. Quantitative data were collected via interviews using the WHOQOL-BREF instrument, while qualitative data were gathered through In-depth interview questions for Key informants and focus group discussions. Quantitative data were analyzed using multivariable logistic regression to identify factors associated with HRQoL, and qualitative data were thematically analyzed to support and contextualize the findings.</p> Results <p>Based on dichotomization using the sample mean, 54.9% (95% CI: 51.1–59.1) of participants had an above-average overall HRQoL score. In adjusted analysis, several characteristics were associated with higher odds of below-average HRQoL: married status (AOR = 4.2; 95% CI: 2.4–7.4) and widowed status (AOR = 14.0; 95% CI: 2.3–85.8) compared with being single; secondary education (vs. diploma and above) (AOR = 8.2; 95% CI: 3.6–19.0); extrapulmonary TB (vs. pulmonary TB) (AOR = 13.5; 95% CI: 7.4–24.7); MDR-TB (vs. non-MDR) (AOR = 25.4; 95% CI: 7.3–88.3); and being in the intensive (Phase I) treatment phase (vs. Phase II) (AOR = 10.1; 95% CI: 5.4–19.2). Qualitative findings highlighted profound social stigma, physical debilitation, and healthcare access challenges as key themes affecting well-being.</p> Conclusion <p>HRQoL among TB patients in the study setting is suboptimal, influenced by marital status, education, TB type, drug resistance, and treatment phase. TB programs should integrate targeted psychosocial support, patient education, and stigma-reduction interventions, with particular attention to married patients, those with EPTB or MDR-TB, and individuals with lower educational attainment. These findings advocate for more holistic, patient-centered care models within national TB control strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Health-related quality of life and associated factors among adult tuberculosis patients in Kembata Zone, Southern Ethiopia: a mixed-methods cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月19日

查看全文
  • Thomas Petros Himbego,
  • Haile Workye Agezhu,
  • Derebe Yohannes Sosengo,
  • Mehari Belayneh Petros,
  • Ayano Elias Gabriel,
  • Abnet Beyene Kobro,
  • Sisay Tagese Tafese,
  • Endalew Dessie Birara,
  • Tamirat Godebo Woyimo

摘要

Background

Tuberculosis (TB) remains a major global public health challenge, significantly impacting morbidity and mortality. Assessing the patient-reported Health-Related Quality of Life (HRQoL) is crucial for understanding the comprehensive burden of TB. This study aimed to evaluate HRQoL and its associated factors among adult TB patients in the Kembata Zone, Southern Ethiopia.

Methods

A concurrent triangulation mixed-methods study was conducted from December 1 to 30, 2023. A multi-stage sampling technique was used to select 597 participants from health facilities across the zone. Quantitative data were collected via interviews using the WHOQOL-BREF instrument, while qualitative data were gathered through In-depth interview questions for Key informants and focus group discussions. Quantitative data were analyzed using multivariable logistic regression to identify factors associated with HRQoL, and qualitative data were thematically analyzed to support and contextualize the findings.

Results

Based on dichotomization using the sample mean, 54.9% (95% CI: 51.1–59.1) of participants had an above-average overall HRQoL score. In adjusted analysis, several characteristics were associated with higher odds of below-average HRQoL: married status (AOR = 4.2; 95% CI: 2.4–7.4) and widowed status (AOR = 14.0; 95% CI: 2.3–85.8) compared with being single; secondary education (vs. diploma and above) (AOR = 8.2; 95% CI: 3.6–19.0); extrapulmonary TB (vs. pulmonary TB) (AOR = 13.5; 95% CI: 7.4–24.7); MDR-TB (vs. non-MDR) (AOR = 25.4; 95% CI: 7.3–88.3); and being in the intensive (Phase I) treatment phase (vs. Phase II) (AOR = 10.1; 95% CI: 5.4–19.2). Qualitative findings highlighted profound social stigma, physical debilitation, and healthcare access challenges as key themes affecting well-being.

Conclusion

HRQoL among TB patients in the study setting is suboptimal, influenced by marital status, education, TB type, drug resistance, and treatment phase. TB programs should integrate targeted psychosocial support, patient education, and stigma-reduction interventions, with particular attention to married patients, those with EPTB or MDR-TB, and individuals with lower educational attainment. These findings advocate for more holistic, patient-centered care models within national TB control strategies.