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Objective <p>This study aimed to systematically identify and evaluate prognostic risk factors for 30-day mortality in patients with sepsis through a meta-analysis.</p> Methods <p>Chinese and English databases were comprehensively searched from the start of the study to January 2025. Observational studies reporting multi-variable adjusted risk ratios (HRS) for prognostic factors of sepsis in adults were included. Data extraction and quality assessment using the Newcastle-Ottawa Scale were performed independently by two reviewers. Meta-analysis was performed using RevMan 5.4.1, and effect estimates were summarized using fixed or random effects models based on heterogeneity.</p> Results <p>Twenty studies involving 69 potential factors were included. A meta-analysis was performed on 15 factors. Increase in age (HR: 1.01), acute kidney injury (HR: 1.48), cancer (HR: 1.21), liver disease (HR: 1.58), septic shock (HR: 2.22), APACHE II (HR: 1.06), SOFA (HR: 1.19), SAPS II score (HR: 1.02), lactate (HR: 1.07) and red blood cell distribution width (HR: 1.07) were significant risk factors. Diabetes (HR: 0.80) and urinary tract infection (HR: 0.47) were protective factors. A high degree of heterogeneity was observed in some factors.</p> Conclusions <p>Multiple factors have a significant impact on the mortality of sepsis. Early identification of these risk factors can guide clinical intervention strategies and improve patient outcomes.</p>

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Prognostic factors of sepsis: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月28日

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  • Chu Qin,
  • Dieyu Ma,
  • Lisha Pang,
  • Mahong Hu,
  • Sisi Lin,
  • Zhizhen Zhou,
  • Xiujuan Xu,
  • Conghua Ji

摘要

Objective

This study aimed to systematically identify and evaluate prognostic risk factors for 30-day mortality in patients with sepsis through a meta-analysis.

Methods

Chinese and English databases were comprehensively searched from the start of the study to January 2025. Observational studies reporting multi-variable adjusted risk ratios (HRS) for prognostic factors of sepsis in adults were included. Data extraction and quality assessment using the Newcastle-Ottawa Scale were performed independently by two reviewers. Meta-analysis was performed using RevMan 5.4.1, and effect estimates were summarized using fixed or random effects models based on heterogeneity.

Results

Twenty studies involving 69 potential factors were included. A meta-analysis was performed on 15 factors. Increase in age (HR: 1.01), acute kidney injury (HR: 1.48), cancer (HR: 1.21), liver disease (HR: 1.58), septic shock (HR: 2.22), APACHE II (HR: 1.06), SOFA (HR: 1.19), SAPS II score (HR: 1.02), lactate (HR: 1.07) and red blood cell distribution width (HR: 1.07) were significant risk factors. Diabetes (HR: 0.80) and urinary tract infection (HR: 0.47) were protective factors. A high degree of heterogeneity was observed in some factors.

Conclusions

Multiple factors have a significant impact on the mortality of sepsis. Early identification of these risk factors can guide clinical intervention strategies and improve patient outcomes.