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Background <p>Catheter-associated urinary tract infections (CAUTIs) are a major healthcare-associated infection (HAI) in trauma care settings, contributing to morbidity, mortality and antimicrobial resistance. In this study we characterize the epidemiology, microbiological profile, antimicrobial resistance patterns, and clinical outcomes of CAUTIs and non-CAUTI urinary tract infections (UTIs) at a Level 1 Trauma Centre in India from 2017 to 2024, using a modified CDC-NHSN definition and digital surveillance.</p> Methods <p>A retrospective analysis of 723 UTI events was conducted using Centers for Disease Control and Prevention’s National Healthcare Safety Network (CDC-NHSN) definitions, modified to include <i>Candida</i> spp. at ≥ 10<sup>5</sup> CFU/mL. Surveillance was performed by dedicated Hospital Infection Control Nurses (HICNs) using a digital system. Microbiological identification and antimicrobial susceptibility testing (AST) were conducted via the conventional manual methods and automated systems.</p> Results <p>of 723 UTI events, 608 (84.0%) were CAUTIs. The cohort had a median age of 34 years (IQR:22–45) and was 76% male. <i>Pseudomonas aeruginosa</i> (18%), <i>Klebsiella pneumoniae</i> (17.9%), and <i>Escherichia coli</i> (15%) were predominant pathogens. Antimicrobial resistance was high, with 100% resistance to ceftazidime in <i>Acinetobacter baumannii</i> and 93.6–94.1% resistance to ciprofloxacin in <i>Klebsiella</i> spp. and <i>Enterococcus</i> spp. Mortality was 25.5% (28.2% in CAUTI, 12.9% in non-CAUTI).</p> Conclusion <p>This large-scale, trauma specific study with modified fungal criteria and digital surveillance highlights the importance of CAUTI burden and the high resistance in pathogens causing this infection.</p> Clinical trial number <p>Not applicable.</p>

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Epidemiological and antimicrobial resistance profile of catheter-associated and non-catheter urinary tract infections in trauma patients (2017–2024)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月30日

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  • Parul Singh,
  • M. Nizam Ahmed,
  • Arpan Kumar Thakur,
  • Ashish Kumar Srivastava,
  • Mamta Puraswani,
  • Bharat Chandra Das,
  • Madhavi Kirti,
  • Vanlal Tluanpuii,
  • Rasna Parveen,
  • Kumari Vandana Singh,
  • Subodh Kumar,
  • Sushma Sagar,
  • Kapil Dev Soni,
  • Richa Aggarwal,
  • Ashish Bindra,
  • Keshav Goyal,
  • Gyanendra Pal Singh,
  • Navdeep Sokhal,
  • Kamran Farooque,
  • Purva Mathur

摘要

Background

Catheter-associated urinary tract infections (CAUTIs) are a major healthcare-associated infection (HAI) in trauma care settings, contributing to morbidity, mortality and antimicrobial resistance. In this study we characterize the epidemiology, microbiological profile, antimicrobial resistance patterns, and clinical outcomes of CAUTIs and non-CAUTI urinary tract infections (UTIs) at a Level 1 Trauma Centre in India from 2017 to 2024, using a modified CDC-NHSN definition and digital surveillance.

Methods

A retrospective analysis of 723 UTI events was conducted using Centers for Disease Control and Prevention’s National Healthcare Safety Network (CDC-NHSN) definitions, modified to include Candida spp. at ≥ 105 CFU/mL. Surveillance was performed by dedicated Hospital Infection Control Nurses (HICNs) using a digital system. Microbiological identification and antimicrobial susceptibility testing (AST) were conducted via the conventional manual methods and automated systems.

Results

of 723 UTI events, 608 (84.0%) were CAUTIs. The cohort had a median age of 34 years (IQR:22–45) and was 76% male. Pseudomonas aeruginosa (18%), Klebsiella pneumoniae (17.9%), and Escherichia coli (15%) were predominant pathogens. Antimicrobial resistance was high, with 100% resistance to ceftazidime in Acinetobacter baumannii and 93.6–94.1% resistance to ciprofloxacin in Klebsiella spp. and Enterococcus spp. Mortality was 25.5% (28.2% in CAUTI, 12.9% in non-CAUTI).

Conclusion

This large-scale, trauma specific study with modified fungal criteria and digital surveillance highlights the importance of CAUTI burden and the high resistance in pathogens causing this infection.

Clinical trial number

Not applicable.