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Background <p><i>Chlamydia trachomatis</i> (C. <i>trachomatis</i>) is known as a leading cause of one of the most prominent sexually transmitted diseases (STD) worldwide. A meta-analysis was performed in this study to comprehensively determine the prevalence of C. <i>trachomatis</i> in the STD population.</p> Method <p>PubMed/Medline, Embase, and Web of Science databases were used to conduct an extensive literature search on relevant papers published from 2000 to 2023. After that, statistical analysis was performed utilizing comprehensive meta-analysis (CMA) software (version 2.0, Biostat, USA) to report the global prevalence of C. <i>trachomatis</i> in the STD population.</p> Result <p>In prevalence studies involving an overall number of 40,159 STD individuals, 17,289 <i>C. trachomatis</i> isolates were collected in 86 countries worldwide, either by culture or by indirect DNA testing. The pooled prevalence of <i>C. trachomatis</i> within the global STD population was 41.6% (95% CI,40.1–43%), while a higher rate was recorded for males (12807 vs. 18871). The prevalence of <i>C. trachomatis</i> infection was highest in Oceania, followed by Europe, America, Asia, and Africa (49.9%, 46.3%, 41.3%, 41.1%, and 36.1%, respectively). According to data from case reports and case series, lymphogranuloma venereum (LGV) and human immunodeficiency virus (HIV) infection were the most common concurrent diseases and co-infections.</p> Conclusion <p>The elevated prevalence of <i>C. trachomatis</i> in 86 countries suggests that innovative screening and infection-prevention programs are required to reduce the burden of this clinically very significant bacterial infection. Our results support the demand for further fundamental investigations in this area especially among HIV-positive patients.</p>

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Global mapping of sexually transmitted Chlamydia trachomatis disease: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月22日

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  • Fatemeh Sameni,
  • Tala Hajiarab,
  • Sara Bayat,
  • Mehrshad Ahmadi,
  • Alex van Belkum,
  • Ali Dadashi,
  • Mehdi Goudarzi,
  • Masoud Dadashi

摘要

Background

Chlamydia trachomatis (C. trachomatis) is known as a leading cause of one of the most prominent sexually transmitted diseases (STD) worldwide. A meta-analysis was performed in this study to comprehensively determine the prevalence of C. trachomatis in the STD population.

Method

PubMed/Medline, Embase, and Web of Science databases were used to conduct an extensive literature search on relevant papers published from 2000 to 2023. After that, statistical analysis was performed utilizing comprehensive meta-analysis (CMA) software (version 2.0, Biostat, USA) to report the global prevalence of C. trachomatis in the STD population.

Result

In prevalence studies involving an overall number of 40,159 STD individuals, 17,289 C. trachomatis isolates were collected in 86 countries worldwide, either by culture or by indirect DNA testing. The pooled prevalence of C. trachomatis within the global STD population was 41.6% (95% CI,40.1–43%), while a higher rate was recorded for males (12807 vs. 18871). The prevalence of C. trachomatis infection was highest in Oceania, followed by Europe, America, Asia, and Africa (49.9%, 46.3%, 41.3%, 41.1%, and 36.1%, respectively). According to data from case reports and case series, lymphogranuloma venereum (LGV) and human immunodeficiency virus (HIV) infection were the most common concurrent diseases and co-infections.

Conclusion

The elevated prevalence of C. trachomatis in 86 countries suggests that innovative screening and infection-prevention programs are required to reduce the burden of this clinically very significant bacterial infection. Our results support the demand for further fundamental investigations in this area especially among HIV-positive patients.