Scholarlink

Background <p>COVID-19 has become a common infectious disease globally and predicting prognosis of hospitalized COVID-19 patients is important, especially for patients with risk factors like febrile neutropenia. Our research aimed to analyze prognostic factors of COVID-19 patients with neutropenia and develop effective scoring system to predict the mortality in these patients.</p> Methods <p>Data of COVID-19 patients with neutropenia who presented to the emergency department were extracted from electronic health records across multiple hospitals between April 2021 and September 2022. The primary outcome was in-hospital mortality. Various scoring systems, including the Multinational Association for Supportive Care in Cancer risk index (MASCC) score, World Health Organization (WHO) ordinal scale, and the combination of these two scoring systems, were used and compared for prediction of prognosis.</p> Results <p>A total of 304 adult COVID-19 in-hospital patients with neutropenia were included into the study. Higher rates of intubation, oxygen use, and ICU admission were observed in the non-survival group. The MASCC score, the WHO ordinal scale and the combined scoring system showed predictive ability for in-hospital mortality, and the combined scoring system had the best predictive power.</p> Conclusion <p>Although MASCC score and WHO ordinal score were useful to predict the prognosis of COVID-19 patients with neutropenia, the new system combining MASCC score and WHO ordinal scale had the best performance in predicting the mortality. Intubation, body temperature, and creatine level were the most significant prognostic factors.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

New scoring system combining WHO ordinal scale and MASCC score in predicting mortality of COVID-19 patients with malignancy and neutropenia: a retrospective cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月14日

查看全文
  • Pin-Chen Lin,
  • Yan-Bo Huang,
  • Feng-Che Kuan,
  • Chip-Jin Ng,
  • Shou-Yen Chen

摘要

Background

COVID-19 has become a common infectious disease globally and predicting prognosis of hospitalized COVID-19 patients is important, especially for patients with risk factors like febrile neutropenia. Our research aimed to analyze prognostic factors of COVID-19 patients with neutropenia and develop effective scoring system to predict the mortality in these patients.

Methods

Data of COVID-19 patients with neutropenia who presented to the emergency department were extracted from electronic health records across multiple hospitals between April 2021 and September 2022. The primary outcome was in-hospital mortality. Various scoring systems, including the Multinational Association for Supportive Care in Cancer risk index (MASCC) score, World Health Organization (WHO) ordinal scale, and the combination of these two scoring systems, were used and compared for prediction of prognosis.

Results

A total of 304 adult COVID-19 in-hospital patients with neutropenia were included into the study. Higher rates of intubation, oxygen use, and ICU admission were observed in the non-survival group. The MASCC score, the WHO ordinal scale and the combined scoring system showed predictive ability for in-hospital mortality, and the combined scoring system had the best predictive power.

Conclusion

Although MASCC score and WHO ordinal score were useful to predict the prognosis of COVID-19 patients with neutropenia, the new system combining MASCC score and WHO ordinal scale had the best performance in predicting the mortality. Intubation, body temperature, and creatine level were the most significant prognostic factors.