Scholarlink

Background <p>Sepsis is a life-threatening syndrome characterized by multiple organ dysfunction resulting from a maladjusted host response to infection. It remains a leading cause of morbidity and mortality worldwide. Early intervention for sepsis improves clinical outcomes. This study aimed to develop a diagnostic and prognostic indicator at the onset of sepsis.</p> Methods <p>From January 2021 to December 2023, patients in the emergency department (ED) were evaluated for the use of Fibulin2 as a diagnostic and prognostic indicator for sepsis. The levels of Fibulin2 in plasma were detected via enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curves were generated to assess the performance of Fibulin2 for predicting sepsis.</p> Results <p>The level of serum Fibulin2 was significantly higher in patients with sepsis than in controls, and Fibulin2 had diagnostic value for sepsis and performed better than C-reactive protein (CRP), procalcitonin (PCT), the white blood cell count (WBC), the neutrophil ratio (NEU%), and D-dimer. Overall, Fibulin2 was upregulated in patients with septic shock compared with septic patients without shock, and Fibulin2 can be used to diagnose septic shock. Moreover, Fibulin2 was increased in patients who died at 28 days of sepsis and had the potential to predict 28-day mortality.</p> Conclusion <p>Fibulin2 may serve as a diagnostic and prognostic biomarker for sepsis in the ED.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fibulin2 is a good diagnostic and prognostic indicator for sepsis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月13日

查看全文
  • Xiaowen Gao,
  • Shidan Li,
  • Jinze Wu,
  • Yiyun Feng,
  • Wei Xing,
  • Xiaoming Li,
  • Yimin Du,
  • Debin Guo,
  • Honghao Xu,
  • Dongqin Tang,
  • Shaochuan Wang,
  • Youbin Li,
  • Jing Yang,
  • Jianfei Ma,
  • Yamei Zhang,
  • Lei Li,
  • Jun Fei

摘要

Background

Sepsis is a life-threatening syndrome characterized by multiple organ dysfunction resulting from a maladjusted host response to infection. It remains a leading cause of morbidity and mortality worldwide. Early intervention for sepsis improves clinical outcomes. This study aimed to develop a diagnostic and prognostic indicator at the onset of sepsis.

Methods

From January 2021 to December 2023, patients in the emergency department (ED) were evaluated for the use of Fibulin2 as a diagnostic and prognostic indicator for sepsis. The levels of Fibulin2 in plasma were detected via enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curves were generated to assess the performance of Fibulin2 for predicting sepsis.

Results

The level of serum Fibulin2 was significantly higher in patients with sepsis than in controls, and Fibulin2 had diagnostic value for sepsis and performed better than C-reactive protein (CRP), procalcitonin (PCT), the white blood cell count (WBC), the neutrophil ratio (NEU%), and D-dimer. Overall, Fibulin2 was upregulated in patients with septic shock compared with septic patients without shock, and Fibulin2 can be used to diagnose septic shock. Moreover, Fibulin2 was increased in patients who died at 28 days of sepsis and had the potential to predict 28-day mortality.

Conclusion

Fibulin2 may serve as a diagnostic and prognostic biomarker for sepsis in the ED.