Background <p><i>Desulfovibrio desulfuricans</i> rarely causes blood infection and is usually associated with intestinal infection. Here, we describe a case of bacteraemia with no clear portal of entry and complicated with a large intracardiac mass.</p> Case presentation <p>A 77-year-old woman was admitted with septic shock and multiorgan failure with hepatic disturbances but no morphologic biliary abnormalities. The echocardiography conducted for the hemodynamic evaluation revealed a large left atrium mass with embolic cerebral complications. She had no history of abdominal infection nor cardiac pathology but bacteraemia was proven with <i>Desulfovibrio desulfuricans</i>, which was effectively treated with piperacillin-tazobactam. She died because of multiorgan failure and refused cardiac surgery.</p> Conclusions <p>Case report of <i>Desulfovibrio desulfuricans</i> bacteraemia complicated by intracardiac thrombus with no abdominal nor respiratory clear history.</p>