Scholarlink

Purpose <p>To evaluate the detection rate of septic metastases in catheter-related <i>S. aureus</i> bacteremia (CR-SAB) episodes by using [18F]FDG-PET/CT.</p> Methods <p>We conducted a retrospective, before-and-after, single-center study of a prospectively identified catheter-related SAB (CR-SAB) cohort at Hospital Clínic Barcelona. All adult patients hospitalized from January 2006 to December 2022 were included. Primary outcome was the detection of septic metastases before and after integrating [18F]FDG-PET/CT into the diagnostic workflow of CR-SAB in January 2020. Secondary outcomes included 30-day mortality, length of stay, and treatment duration.</p> Results <p>A total of 598 episodes of CR-SAB were included, 100 in the post-intervention period (2020–2022) and 498 in the pre-intervention period (2006–2019). [18F]FDG-PET/CT scan was performed in 28/100 episodes (28.0%) in post-intervention period, versus 9/498 in pre-intervention period (1.8%). Septic metastases detection rate was higher after [18F]FDG-PET/CT implementation (22/100, 22% <i>vs.</i> 56/498, 11.2% <i>p</i> .004), mainly due to pulmonary septic emboli (13/100, 13.0% <i>vs</i>. 12/498, 2.4% <i>p </i>&lt; .001) and osteoarticular seeding (7/100, 7.0% <i>vs</i>. 11/498, 2.2% <i>p</i> .019). Neither pulmonary septic emboli nor osteoarticular metastases increased 30-day mortality (3/25, 12.0% vs. 57/573, 10.0%, <i>p</i> .732; and 2/18, 11.1% vs. 58/580 10.0%, <i>p</i> .702, respectively). Patients with septic metastases had longer treatment [25.0 (16.0–37.0) <i>vs</i>. 15.0 (13.0–19.0) days, <i>p</i> &lt; .001].</p> Conclusions <p>[18F]FDG-PET/CT use in patients with CR-SAB was associated with a higher rate of septic metastases diagnosis, mainly pulmonary and osteoarticular, resulting in longer treatment, but no differences in clinical outcomes were observed.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Detection of septic metastases in catheter-related Staphylococcus aureus bacteremia using 18FFDG-PET/CT: a before-and-after study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月7日

查看全文
  • Miguel Ángel Verdejo,
  • Andrés Perissinotti,
  • Daniela Malano-Barletta,
  • Cristina Pitart,
  • Guillermo Cuervo,
  • Marta Hernández-Meneses,
  • Marta Bodro,
  • Sabina Herrera,
  • Carolina García-Vidal,
  • Pedro Puerta-Alcalde,
  • José Antonio Martínez,
  • Ana del Río,
  • Mateu Espasa,
  • David Fuster,
  • Laura Morata,
  • Alex Soriano

摘要

Purpose

To evaluate the detection rate of septic metastases in catheter-related S. aureus bacteremia (CR-SAB) episodes by using [18F]FDG-PET/CT.

Methods

We conducted a retrospective, before-and-after, single-center study of a prospectively identified catheter-related SAB (CR-SAB) cohort at Hospital Clínic Barcelona. All adult patients hospitalized from January 2006 to December 2022 were included. Primary outcome was the detection of septic metastases before and after integrating [18F]FDG-PET/CT into the diagnostic workflow of CR-SAB in January 2020. Secondary outcomes included 30-day mortality, length of stay, and treatment duration.

Results

A total of 598 episodes of CR-SAB were included, 100 in the post-intervention period (2020–2022) and 498 in the pre-intervention period (2006–2019). [18F]FDG-PET/CT scan was performed in 28/100 episodes (28.0%) in post-intervention period, versus 9/498 in pre-intervention period (1.8%). Septic metastases detection rate was higher after [18F]FDG-PET/CT implementation (22/100, 22% vs. 56/498, 11.2% p .004), mainly due to pulmonary septic emboli (13/100, 13.0% vs. 12/498, 2.4% p < .001) and osteoarticular seeding (7/100, 7.0% vs. 11/498, 2.2% p .019). Neither pulmonary septic emboli nor osteoarticular metastases increased 30-day mortality (3/25, 12.0% vs. 57/573, 10.0%, p .732; and 2/18, 11.1% vs. 58/580 10.0%, p .702, respectively). Patients with septic metastases had longer treatment [25.0 (16.0–37.0) vs. 15.0 (13.0–19.0) days, p < .001].

Conclusions

[18F]FDG-PET/CT use in patients with CR-SAB was associated with a higher rate of septic metastases diagnosis, mainly pulmonary and osteoarticular, resulting in longer treatment, but no differences in clinical outcomes were observed.