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Background <p>Transfusion-transmitted infections (TTIs), such as HIV, HBV, HCV, and Syphilis, present considerable difficulties in maintaining blood quality despite the critical role of blood transfusion in emergency medical care. This study aims to ascertain the prevalence of these infections and the factors that increase their risk among those who donate blood.</p> Methods <p>A cross-sectional study was conducted at the Federal Medical Center in Azare, involving 400 blood donors. Serological tests were conducted for HBV, HCV, HIV, and syphilis, and sociodemographic data was collected through a structured questionnaire. The univariate and multivariate logistic regression tests were employed to detect associated risk factors, with a significance level set at <i>P</i> &lt; 0.05.</p> Result <p>Of the total blood donors, 17.00% (68/400) tested positive for at least one TTIs. The presence of HIV, HBV, HCV, and syphilis was identified in 2.8% (11/400), 8.3% (33/400), 1.8% (7/400), and 4.3% (17/400) of the donors, respectively. Multivariate analysis, after adjustments with various variables, indicates only commercial blood donors [Adjusted Odds Ratio (AOR) (95% CI): 14.63 (1.76-121.27)] and multiple sexual partners [AOR (95% CI): 5.40 (1.28–22.70)] were associated with HIV, while blood transfusion and piercing or tattoo were associated with HBV. Multiple sexual partners and a history of STDs were associated with syphilis infection.</p> Conclusion <p>TTIs such as HIV, HBV, HCV, and syphilis were detected among the blood donors, with HBV being the most common. The findings highlight a gender disparity in blood donation, with voluntary donors comprising the majority; nevertheless, commercial donors had the highest prevalence of TTIs. Enhanced donor screening and public awareness are crucial for blood safety.</p> Clinical trial number <p>Not applicable.</p>

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Seroprevalence of HIV, HBV, HCV and Syphilis among blood donors in a Nigerian tertiary medical centre

  • 期刊论文

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  • 发表日期：

    2025年4月30日

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  • Ismail Habibu,
  • Bashir Mohammed Abubakar,
  • Ibrahim Musa Moi,
  • Rabiu Abdulrazaq

摘要

Background

Transfusion-transmitted infections (TTIs), such as HIV, HBV, HCV, and Syphilis, present considerable difficulties in maintaining blood quality despite the critical role of blood transfusion in emergency medical care. This study aims to ascertain the prevalence of these infections and the factors that increase their risk among those who donate blood.

Methods

A cross-sectional study was conducted at the Federal Medical Center in Azare, involving 400 blood donors. Serological tests were conducted for HBV, HCV, HIV, and syphilis, and sociodemographic data was collected through a structured questionnaire. The univariate and multivariate logistic regression tests were employed to detect associated risk factors, with a significance level set at P < 0.05.

Result

Of the total blood donors, 17.00% (68/400) tested positive for at least one TTIs. The presence of HIV, HBV, HCV, and syphilis was identified in 2.8% (11/400), 8.3% (33/400), 1.8% (7/400), and 4.3% (17/400) of the donors, respectively. Multivariate analysis, after adjustments with various variables, indicates only commercial blood donors [Adjusted Odds Ratio (AOR) (95% CI): 14.63 (1.76-121.27)] and multiple sexual partners [AOR (95% CI): 5.40 (1.28–22.70)] were associated with HIV, while blood transfusion and piercing or tattoo were associated with HBV. Multiple sexual partners and a history of STDs were associated with syphilis infection.

Conclusion

TTIs such as HIV, HBV, HCV, and syphilis were detected among the blood donors, with HBV being the most common. The findings highlight a gender disparity in blood donation, with voluntary donors comprising the majority; nevertheless, commercial donors had the highest prevalence of TTIs. Enhanced donor screening and public awareness are crucial for blood safety.

Clinical trial number

Not applicable.