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<p>The recurrence of latent toxoplasmosis is a frequent cause of toxoplasmic encephalopathy in individuals with immunosuppressive conditions or medication. If left untreated or diagnosed is delayed, it often resulting in fatality. The pathogen of Toxoplasma gondii has been identified in cerebrospinal fluid cytology and a limited number of documented cases of cerebral toxoplasmosis, typically observed in those with acquired immunodeficiency syndrome (AIDS). We report the identification of Toxoplasma gondii tachyzoites in the cerebrospinal fluid of a patient diagnosed with systemic lupus erythematosus (SLE) and concurrent SARS-CoV-2 positive infection. The presented case suggests that cerebral toxoplasmosis should be promptly considered when patients with systemic lupus erythematosus exhibit neurological manifestations.</p>

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Detection of toxoplasma tachyzoites in the cerebrospinal fluid of a COVID-19 positive SLE patient: a case study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月7日

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  • Ling Chen,
  • Xiangping Hou,
  • Hao Fu,
  • Rui Zheng,
  • Yonghong Xiao,
  • Lifeng Xiang,
  • Yunhua Dong

摘要

The recurrence of latent toxoplasmosis is a frequent cause of toxoplasmic encephalopathy in individuals with immunosuppressive conditions or medication. If left untreated or diagnosed is delayed, it often resulting in fatality. The pathogen of Toxoplasma gondii has been identified in cerebrospinal fluid cytology and a limited number of documented cases of cerebral toxoplasmosis, typically observed in those with acquired immunodeficiency syndrome (AIDS). We report the identification of Toxoplasma gondii tachyzoites in the cerebrospinal fluid of a patient diagnosed with systemic lupus erythematosus (SLE) and concurrent SARS-CoV-2 positive infection. The presented case suggests that cerebral toxoplasmosis should be promptly considered when patients with systemic lupus erythematosus exhibit neurological manifestations.