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Objects <p>This study examines how social isolation affects the relationship between childhood friendships and frailty in older adults, aiming to provide insights for improving their health.</p> Design <p>A Longitudinal study guided by the Strengthening the Reporting of Observational Studies in Epidemiology.</p> Methods <p>Data from the CHARLS database (2014, 2015, 2018) were analyzed. Correlation, regression, and mediation analyses were used to explore the relationships between childhood friendships, social isolation, and frailty.</p> Results <p>Among 4,132 participants, 1,363 (33.0%) were identified as frail. Childhood friendships were negatively associated with frailty and social isolation, while social isolation was positively associated with frailty. Mediation analysis showed a significant indirect effect (-0.0040, 95% CI: -0.0055, -0.0027), indicating that social isolation mediates the relationship between childhood friendships and frailty.</p> Conclusion <p>Social isolation can exacerbate the effects of adverse childhood experiences on subsequent frailty. Targeted interventions should be developed to reduce social isolation and maintain health in older adults.</p>

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The role of social isolation in the association between childhood friendships and frailty in older adults: evidence from a national cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月11日

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  • Bin Ma,
  • Yue Hou,
  • Yuanmin Jia,
  • Yanhong Dong,
  • Mengyuan Zhang,
  • Hecun Xiao,
  • Ou Chen

摘要

Objects

This study examines how social isolation affects the relationship between childhood friendships and frailty in older adults, aiming to provide insights for improving their health.

Design

A Longitudinal study guided by the Strengthening the Reporting of Observational Studies in Epidemiology.

Methods

Data from the CHARLS database (2014, 2015, 2018) were analyzed. Correlation, regression, and mediation analyses were used to explore the relationships between childhood friendships, social isolation, and frailty.

Results

Among 4,132 participants, 1,363 (33.0%) were identified as frail. Childhood friendships were negatively associated with frailty and social isolation, while social isolation was positively associated with frailty. Mediation analysis showed a significant indirect effect (-0.0040, 95% CI: -0.0055, -0.0027), indicating that social isolation mediates the relationship between childhood friendships and frailty.

Conclusion

Social isolation can exacerbate the effects of adverse childhood experiences on subsequent frailty. Targeted interventions should be developed to reduce social isolation and maintain health in older adults.