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Background <p>The efficacy of supplementation with branched-chain amino acids (BCAAs) and vitamin D with exercise in elderly people remains unclear. This study aimed to examine whether the combination of exercise and supplementation with BCAA- and vitamin D-containing high-protein food would be effective in improving soft lean mass and physical functions in elderly people with impaired physical functions.</p> Methods <p>This 12-week interventional study recruited elderly people ≥ 60&#xa0;years of age with impaired physical activity (locomotive syndrome, LS). The participants were assigned to one of the following three groups: exercise group (group EX, <i>n</i> = 46), exercise with supplementation of BCAA- and vitamin D-containing high-protein food group (group EF, <i>n</i> = 45), and control group (group C, <i>n</i> = 31). Subjects in group EX were instructed to perform locomotion training, and those in group EF were instructed to consume high-protein test food in addition to locomotion training. The soft lean mass, a self-administered questionnaire (Geriatric Locomotive Function Scale-25, GLFS-25) and physical tests (stand-up test, two-step test), and the value of 25OH vitamin D were compared among the three groups after three months of intervention.</p> Results <p>There were no significant declines in soft lean mass in group EF, while significant declines were detected in the other two groups. There were significant differences in the stand-up test scores among the three groups (<i>p</i> = 0.03). A post-hoc analysis showed a significant difference between groups C and EF. There was a significant difference in the two-step test scores among the three groups (<i>p</i> = 0.004). A post-hoc analysis showed significant differences between groups C and EX, and between groups C and EF. There were no significant differences in the GLFS-25 scores among the groups. There was a significant increase in the value of 25OH vitamin D after three months in group EF (<i>p</i> &lt; 0.001).</p> Conclusions <p>This study showed that BCAA and vitamin D supplementation with exercise in elderly subjects with declining physical functions resulted in maintenance of soft lean mass, improvement in physical functions (stand-up test score and two-step test), and an increase in 25OH vitamin D.</p> Trial registration <p>This study was prospectively registered at the University Hospital Medical Information Network on 01/02/2018 (UMIN000030567).</p>

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Effects of branched-chain amino acid- and vitamin D-containing high-protein food supplementation plus exercise on elderly people with decreased physical functions

  • 期刊论文

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  • 发表日期：

    2025年7月5日

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  • Yoshihiro Nakamura,
  • Takuji Yokoe,
  • Koki Ouchi,
  • Taro Funamoto,
  • Hiroyuki Kimura,
  • Koichiro Hamada,
  • Hideki Arakawa,
  • Etsuo Chosa,
  • Naosuke Kamei

摘要

Background

The efficacy of supplementation with branched-chain amino acids (BCAAs) and vitamin D with exercise in elderly people remains unclear. This study aimed to examine whether the combination of exercise and supplementation with BCAA- and vitamin D-containing high-protein food would be effective in improving soft lean mass and physical functions in elderly people with impaired physical functions.

Methods

This 12-week interventional study recruited elderly people ≥ 60 years of age with impaired physical activity (locomotive syndrome, LS). The participants were assigned to one of the following three groups: exercise group (group EX, n = 46), exercise with supplementation of BCAA- and vitamin D-containing high-protein food group (group EF, n = 45), and control group (group C, n = 31). Subjects in group EX were instructed to perform locomotion training, and those in group EF were instructed to consume high-protein test food in addition to locomotion training. The soft lean mass, a self-administered questionnaire (Geriatric Locomotive Function Scale-25, GLFS-25) and physical tests (stand-up test, two-step test), and the value of 25OH vitamin D were compared among the three groups after three months of intervention.

Results

There were no significant declines in soft lean mass in group EF, while significant declines were detected in the other two groups. There were significant differences in the stand-up test scores among the three groups (p = 0.03). A post-hoc analysis showed a significant difference between groups C and EF. There was a significant difference in the two-step test scores among the three groups (p = 0.004). A post-hoc analysis showed significant differences between groups C and EX, and between groups C and EF. There were no significant differences in the GLFS-25 scores among the groups. There was a significant increase in the value of 25OH vitamin D after three months in group EF (p < 0.001).

Conclusions

This study showed that BCAA and vitamin D supplementation with exercise in elderly subjects with declining physical functions resulted in maintenance of soft lean mass, improvement in physical functions (stand-up test score and two-step test), and an increase in 25OH vitamin D.

Trial registration

This study was prospectively registered at the University Hospital Medical Information Network on 01/02/2018 (UMIN000030567).