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Aim <p>To evaluate the potential benefit of external mirabilite dressing combined with abdominal drainage for treating severe acute pancreatitis (SAP).</p> Methods <p>This retrospective study included SAP patients from two centres who were divided into three groups: combined therapy (A, <i>n</i> = 24), mirabilite alone (B, <i>n</i> = 31), and drainage alone (C, <i>n</i> = 25). The outcomes included symptom recovery, laboratory parameters, intra-abdominal pressure (IAP), imaging findings, complications, and costs. Quantile regression adjusted for the Ranson score was performed.</p> Results <p>Despite the higher baseline Ranson score in Group A (4.00 vs. 3.00 in B and 4.00 in C; <i>p</i> = 0.026), Group A had a faster time to abdominal pain relief (7.50 vs. 11.00 and 9.00 days; <i>P</i> = 0.016), a faster time to flatus (2.00 vs. 3.00 and 2.00 days; <i>P</i> = 0.042), and faster white blood cell count normalization (3.00 vs. 6.00 and 5.00 days; <i>P</i> = 0.049). The IAP at discharge was lowest in Group A (7.35 vs. 8.46 and 8.82 mmHg, <i>P</i> = 0.032). Exudate area reduction (741.06 vs. 164.03 and 494.20&#xa0;mm², <i>P</i> = 0.001) and pseudocyst area (323.94 vs. 484.30 and 453.38&#xa0;mm², <i>P</i> = 0.038) were also both better in Group A. No differences were observed in the incidence of complications or health economic indicators (all <i>p</i> &gt; 0.05).</p> Conclusion <p>In this retrospective, non-randomized study, combining external mirabilite dressing with abdominal drainage in early-stage SAP patients was associated with short-term clinical benefits without increasing total hospitalization costs. These findings are hypothesis-generating and require prospective validation.</p>

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Potential benefit of mirabilite external dressing combined with abdominal drainage in the early stage of severe acute pancreatitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Jing-xian Zhang,
  • Han-shu Jin,
  • Shuang-shuang Lu,
  • Yu-hui Sun,
  • Kuang-jing Wang,
  • Jin Huang

摘要

Aim

To evaluate the potential benefit of external mirabilite dressing combined with abdominal drainage for treating severe acute pancreatitis (SAP).

Methods

This retrospective study included SAP patients from two centres who were divided into three groups: combined therapy (A, n = 24), mirabilite alone (B, n = 31), and drainage alone (C, n = 25). The outcomes included symptom recovery, laboratory parameters, intra-abdominal pressure (IAP), imaging findings, complications, and costs. Quantile regression adjusted for the Ranson score was performed.

Results

Despite the higher baseline Ranson score in Group A (4.00 vs. 3.00 in B and 4.00 in C; p = 0.026), Group A had a faster time to abdominal pain relief (7.50 vs. 11.00 and 9.00 days; P = 0.016), a faster time to flatus (2.00 vs. 3.00 and 2.00 days; P = 0.042), and faster white blood cell count normalization (3.00 vs. 6.00 and 5.00 days; P = 0.049). The IAP at discharge was lowest in Group A (7.35 vs. 8.46 and 8.82 mmHg, P = 0.032). Exudate area reduction (741.06 vs. 164.03 and 494.20 mm², P = 0.001) and pseudocyst area (323.94 vs. 484.30 and 453.38 mm², P = 0.038) were also both better in Group A. No differences were observed in the incidence of complications or health economic indicators (all p > 0.05).

Conclusion

In this retrospective, non-randomized study, combining external mirabilite dressing with abdominal drainage in early-stage SAP patients was associated with short-term clinical benefits without increasing total hospitalization costs. These findings are hypothesis-generating and require prospective validation.