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Background <p>To investigate bone, adipose, and muscle-related body compositions changes in gastric cancers (GCs) 12 months after gastrectomy utilizing an artificial intelligence (AI) based segmentation tool and to conduct subgroup analyses based on clinicopathological characteristics.</p> Methods <p>This retrospective study included 146 GCs who underwent gastrectomy. Body compositions of GCs at baseline and 12 months after surgery were automatically measured utilizing the AI-based segmentation tool. The differences in body compositions at baseline and 12 months after surgery were assessed. Subgroup analyses of body composition changes stratified by clinicopathological characteristics were conducted. Benjamini-Hochberg false discovery rate (FDR) correction was utilized for all subgroup analyses.</p> Results <p>All body composition parameters, including bone mineral density (BMD), adipose tissue, and muscle, decreased significantly 12 months after surgery (all <i>p</i> &lt; 0.001). The greatest losses were observed in adipose-related compositions. The proportions of sarcopenia (from 37.7% to 55.5%) and osteoporosis (from 13.7% to 26.7%) showed significant increases. Subcutaneous and visceral adipose tissues, abdominal wall muscle, and skeletal muscle losses indicated significant differences in gender and body mass index (BMI) subgroups (all FDR <i>p</i> &lt; 0.05). Adipose- and muscle-related losses differed significantly in GCs underwent different types of gastrectomy (all FDR <i>p</i> &lt; 0.05), while BMD loss showed no significant difference. Subgroup analyses based on pathological stages showed no significant difference for body composition changes.</p> Conclusions <p>BMD, adipose-related, and muscle-related body compositions showed significant losses over 12 months in GCs underwent gastrectomy. The greatest losses were observed in adipose-related compositions. The proportions of sarcopenia and osteoporosis showed significant increases. Gender, baseline BMI, and gastrectomy differences affected adipose- and muscle-related body composition losses but showed no significant effect on BMD.</p>

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Changes of bone, adipose, and muscle-related body compositions in gastric cancers after gastrectomy using deep learning based automatic segmentation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月10日

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  • Mengying Xu,
  • Dan Liu,
  • Mengze Zhang,
  • Song Liu,
  • Zhengyang Zhou

摘要

Background

To investigate bone, adipose, and muscle-related body compositions changes in gastric cancers (GCs) 12 months after gastrectomy utilizing an artificial intelligence (AI) based segmentation tool and to conduct subgroup analyses based on clinicopathological characteristics.

Methods

This retrospective study included 146 GCs who underwent gastrectomy. Body compositions of GCs at baseline and 12 months after surgery were automatically measured utilizing the AI-based segmentation tool. The differences in body compositions at baseline and 12 months after surgery were assessed. Subgroup analyses of body composition changes stratified by clinicopathological characteristics were conducted. Benjamini-Hochberg false discovery rate (FDR) correction was utilized for all subgroup analyses.

Results

All body composition parameters, including bone mineral density (BMD), adipose tissue, and muscle, decreased significantly 12 months after surgery (all p < 0.001). The greatest losses were observed in adipose-related compositions. The proportions of sarcopenia (from 37.7% to 55.5%) and osteoporosis (from 13.7% to 26.7%) showed significant increases. Subcutaneous and visceral adipose tissues, abdominal wall muscle, and skeletal muscle losses indicated significant differences in gender and body mass index (BMI) subgroups (all FDR p < 0.05). Adipose- and muscle-related losses differed significantly in GCs underwent different types of gastrectomy (all FDR p < 0.05), while BMD loss showed no significant difference. Subgroup analyses based on pathological stages showed no significant difference for body composition changes.

Conclusions

BMD, adipose-related, and muscle-related body compositions showed significant losses over 12 months in GCs underwent gastrectomy. The greatest losses were observed in adipose-related compositions. The proportions of sarcopenia and osteoporosis showed significant increases. Gender, baseline BMI, and gastrectomy differences affected adipose- and muscle-related body composition losses but showed no significant effect on BMD.