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Background <p>To compare the diagnostic accuracy of gadoxetate disodium enhanced MRI (EOB-MRI) and contrast-enhanced CT (CE-CT) in the detection of colorectal cancer liver metastases (CRLM).</p> Methods <p>We conducted a systematic search of PubMed, Embase, web of science, and the Cochrane Library up to 4 November 2025, to identify original studies comparing the accuracy of EOB-MRI with CE-CT in diagnosing CRLM. Pooled sensitivity (SEN) and specificity (SPE) were calculated, and subgroup analyses were performed based on tumor diameter and ethnicity.</p> Results <p>A total of 1,842 patients from 15 studies diagnosed with colorectal cancer were included in the study. The pooled SEN of EOB-MRI was 90.0% [95% confidence interval (CI): 88.0%–92.0%], and the corresponding SPE was 88.0% (95% CI: 85.0%–90.0%). For CE-CT, the pooled SEN was 78.0% (95% CI: 75.0%–80.0%) and SPE was 90.0% (95% CI: 88.0%–92.0%). In subgroup analysis, 98.0% (95% CI: 97.0%–99.0%) of CRLM lesions with a diameter of more than 1&#xa0;cm were detected by EOB-MRI, compared with 95.0% (95% CI: 93.0%–97.0%) for CE-CT, and only one study reported an SPE of 88.0% (95% CI: 79.0%–97.0%) for CE-CT. For CRLM lesions ≤ 1&#xa0;cm in diameter, the pooled SEN of EOB-MRI was 89.0% (95% CI: 85.0%–93.0%) and 29% (95% CI: 21.0%–37.0%) for CE-CT, and only one study reported SPE for both EOB-MRI and CE-CT (88.0% (95% CI: 83.0%–93.0%) and 96.0% (95% CI: 93.0%–99.0%).</p> Conclusion <p>EOB-MRI is more sensitive than CE-CT for detecting CRLM, especially small lesions, and is recommended for clinical use to improve patient outcomes.</p>

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Diagnostic value of Gd-EOB-DTPA-enhanced MRI versus contrast-enhanced CT for detecting liver metastasis in colorectal cancer: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月27日

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  • Shuting Chen,
  • Min Wen,
  • Fangbiao Lv,
  • Lifen Yan,
  • Xiangtian Zhao,
  • Changhong Liang

摘要

Background

To compare the diagnostic accuracy of gadoxetate disodium enhanced MRI (EOB-MRI) and contrast-enhanced CT (CE-CT) in the detection of colorectal cancer liver metastases (CRLM).

Methods

We conducted a systematic search of PubMed, Embase, web of science, and the Cochrane Library up to 4 November 2025, to identify original studies comparing the accuracy of EOB-MRI with CE-CT in diagnosing CRLM. Pooled sensitivity (SEN) and specificity (SPE) were calculated, and subgroup analyses were performed based on tumor diameter and ethnicity.

Results

A total of 1,842 patients from 15 studies diagnosed with colorectal cancer were included in the study. The pooled SEN of EOB-MRI was 90.0% [95% confidence interval (CI): 88.0%–92.0%], and the corresponding SPE was 88.0% (95% CI: 85.0%–90.0%). For CE-CT, the pooled SEN was 78.0% (95% CI: 75.0%–80.0%) and SPE was 90.0% (95% CI: 88.0%–92.0%). In subgroup analysis, 98.0% (95% CI: 97.0%–99.0%) of CRLM lesions with a diameter of more than 1 cm were detected by EOB-MRI, compared with 95.0% (95% CI: 93.0%–97.0%) for CE-CT, and only one study reported an SPE of 88.0% (95% CI: 79.0%–97.0%) for CE-CT. For CRLM lesions ≤ 1 cm in diameter, the pooled SEN of EOB-MRI was 89.0% (95% CI: 85.0%–93.0%) and 29% (95% CI: 21.0%–37.0%) for CE-CT, and only one study reported SPE for both EOB-MRI and CE-CT (88.0% (95% CI: 83.0%–93.0%) and 96.0% (95% CI: 93.0%–99.0%).

Conclusion

EOB-MRI is more sensitive than CE-CT for detecting CRLM, especially small lesions, and is recommended for clinical use to improve patient outcomes.