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Background <p>Patients’ adherence is important for successful <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication, and may be improved by WeChat, a popular social networking platform. This study aimed to evaluate patients’ adherence, successful <i>H. pylori</i> eradication, and clinical remission under the WeChat-based enhanced guidance.</p> Methods <p>Ninety-nine patients with <i>H. pylori</i> infection, who were treated by a 14-day standard bismuth-containing quadruple therapy (BQT) and received the WeChat-based enhanced guidance, were retrospectively included. Multivariate logistic regression analysis was performed to identify independent predictors of patients’ adherence and <i>H. pylori</i> eradication. Odds ratios (ORs) were calculated.</p> Results <p>The rates of good medication adherence, good re-examination adherence, successful <i>H. pylori</i> eradication, and clinical remission were 97.0%, 83.8%, 89.2%, and 89.5%, respectively. Patients with poor re-examination adherence had significantly lower proportions of individual dining (13.3% versus 50.6%,<i> P</i>=0.008) and no smoking during treatment (66.7% versus 92.8%, <i>P</i>=0.012) than those with good re-examination adherence. Both individual dining (OR=0.182, P=0.035) and no smoking during treatment (OR=0.210,<i> P</i>=0.031) were independently associated with good re-examination adherence. Patients with <i>H. pylori</i> eradication failure had significantly higher proportions of poor medication adherence (22.2% versus 1.4%, <i>P</i>=0.030) and living in rural area (44.4% versus 8.1%, <i>P</i>=0.009) than those with <i>H. pylori</i> eradication success. Both poor medication adherence (OR=20.366, <i>P</i>=0.031) and living in rural area (OR=8.944, P=0.010) were independently associated with <i>H. pylori</i> eradication failure.</p> Conclusion <p>There is good medication adherence with satisfactory <i>H. pylori</i> eradication and clinical remission under the WeChat-based enhanced guidance. How to improve re-examination adherence should be further explored.</p> Graphical Abstract <p></p>

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WeChat-based manual enhanced guidance in patients with Helicobacter pylori infection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月28日

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  • Xiaoye Shi,
  • Zhe Li,
  • Zhenhua Tong,
  • Chun Ye,
  • Wentao Xu,
  • Hongyu Li,
  • Xingshun Qi

摘要

Background

Patients’ adherence is important for successful Helicobacter pylori (H. pylori) eradication, and may be improved by WeChat, a popular social networking platform. This study aimed to evaluate patients’ adherence, successful H. pylori eradication, and clinical remission under the WeChat-based enhanced guidance.

Methods

Ninety-nine patients with H. pylori infection, who were treated by a 14-day standard bismuth-containing quadruple therapy (BQT) and received the WeChat-based enhanced guidance, were retrospectively included. Multivariate logistic regression analysis was performed to identify independent predictors of patients’ adherence and H. pylori eradication. Odds ratios (ORs) were calculated.

Results

The rates of good medication adherence, good re-examination adherence, successful H. pylori eradication, and clinical remission were 97.0%, 83.8%, 89.2%, and 89.5%, respectively. Patients with poor re-examination adherence had significantly lower proportions of individual dining (13.3% versus 50.6%, P=0.008) and no smoking during treatment (66.7% versus 92.8%, P=0.012) than those with good re-examination adherence. Both individual dining (OR=0.182, P=0.035) and no smoking during treatment (OR=0.210, P=0.031) were independently associated with good re-examination adherence. Patients with H. pylori eradication failure had significantly higher proportions of poor medication adherence (22.2% versus 1.4%, P=0.030) and living in rural area (44.4% versus 8.1%, P=0.009) than those with H. pylori eradication success. Both poor medication adherence (OR=20.366, P=0.031) and living in rural area (OR=8.944, P=0.010) were independently associated with H. pylori eradication failure.

Conclusion

There is good medication adherence with satisfactory H. pylori eradication and clinical remission under the WeChat-based enhanced guidance. How to improve re-examination adherence should be further explored.

Graphical Abstract