Scholarlink

Purpose <p>Prealbumin, a marker of nutritional and inflammatory status, has shown prognostic value in various malignancies. This study aimed to evaluate the prognostic significance of preoperative serum prealbumin levels in gallbladder cancer (GBC) patients undergoing radical resection.</p> Methods <p>A multicenter retrospective study included 210 patients who underwent radical GBC resection. The optimal prealbumin cutoff (221&#xa0;mg/L) was identified via ROC analysis. Patients were stratified into high and low prealbumin groups. Kaplan–Meier and Cox regression analyses were used to assess the association between prealbumin levels and overall survival (OS) and recurrence-free survival (RFS).</p> Results <p>Patients with low prealbumin levels (<i>n</i> = 120) had 1-year OS and RFS rates of 65% and 44.1%, respectively. In contrast, high prealbumin patients (<i>n</i> = 90) showed significantly better OS (96.6%) and RFS (90%) (<i>p</i> &lt; 0.001). Multivariate analysis confirmed prealbumin as an independent predictor of OS (HR = 0.179, 95% CI: 0.052–0.622, <i>p</i> = 0.007) and RFS (HR = 0.220, 95% CI: 0.102–0.474, <i>p</i> &lt; 0.001). A combined model of prealbumin and hemoglobin improved predictive accuracy for OS (AUC = 0.762) and RFS (AUC = 0.771).</p> Conclusion <p>Preoperative serum prealbumin is an independent prognostic biomarker in GBC patients undergoing radical resection. Combining prealbumin with hemoglobin enhances prediction of postoperative survival.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preoperative serum prealbumin as a prognostic marker for survival after gallbladder cancer resection: a multicenter study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月27日

查看全文
  • Zhenhao Huang,
  • Jixing Wang,
  • Baoyong Zhou,
  • Rui Liao,
  • Jie Xu,
  • Peng Guo,
  • Zhipeng Liu,
  • Nan You,
  • Rui Tao,
  • Qihui Hu

摘要

Purpose

Prealbumin, a marker of nutritional and inflammatory status, has shown prognostic value in various malignancies. This study aimed to evaluate the prognostic significance of preoperative serum prealbumin levels in gallbladder cancer (GBC) patients undergoing radical resection.

Methods

A multicenter retrospective study included 210 patients who underwent radical GBC resection. The optimal prealbumin cutoff (221 mg/L) was identified via ROC analysis. Patients were stratified into high and low prealbumin groups. Kaplan–Meier and Cox regression analyses were used to assess the association between prealbumin levels and overall survival (OS) and recurrence-free survival (RFS).

Results

Patients with low prealbumin levels (n = 120) had 1-year OS and RFS rates of 65% and 44.1%, respectively. In contrast, high prealbumin patients (n = 90) showed significantly better OS (96.6%) and RFS (90%) (p < 0.001). Multivariate analysis confirmed prealbumin as an independent predictor of OS (HR = 0.179, 95% CI: 0.052–0.622, p = 0.007) and RFS (HR = 0.220, 95% CI: 0.102–0.474, p < 0.001). A combined model of prealbumin and hemoglobin improved predictive accuracy for OS (AUC = 0.762) and RFS (AUC = 0.771).

Conclusion

Preoperative serum prealbumin is an independent prognostic biomarker in GBC patients undergoing radical resection. Combining prealbumin with hemoglobin enhances prediction of postoperative survival.