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Background <p>Non-anemic iron deficiency is common in patients with ulcerative colitis; however, it may be underestimated and untreated, negatively impacting the quality of life. Therefore, this study aimed to investigate factors associated with non-anemic iron deficiency in Japanese patients with ulcerative colitis.</p> Methods <p>This cross-sectional study was conducted in Japan between April 2021 and March 2023. The study participants included 112 patients with ulcerative colitis without anemia. Iron deficiency was defined as ferritin levels &lt; 100 and &lt; 30&#xa0;ng/mL in patients with disease activity (defined as Mayo endoscopic subscores ≥ 2) and those without disease activity, respectively.</p> Results <p>Patients with ulcerative colitis without anemia were classified as those with iron deficiency (<i>n</i> = 38) and normal iron status (<i>n</i> = 74). The prevalence of non-anemic iron deficiency was 33.9%. Multivariate analysis revealed that female sex (adjusted odds ratio: 15.40, 95% confidence interval: 2.66–89.00) and non-mucosal healing (adjusted odds ratio: 18.10, 95% confidence interval: 2.97–110.00) were independently associated with non-anemic iron deficiency. Conversely, clinical remission, the use of prednisolone, C-reactive protein level, and transferrin saturation level were not significantly associated with non-anemic iron deficiency.</p> Conclusion <p>Female sex and non-mucosal healing were identified as independent factors significantly associated with the prevalence of non-anemic iron deficiency in patients with ulcerative colitis. Therefore, monitoring of iron dynamics in patients with ulcerative colitis who have these characteristics is recommended even in the absence of anemia.</p> Graphical abstract <p></p>

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Factors associated with ulcerative colitis with non-anemic iron deficiency

  • 期刊论文

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  • 发表日期：

    2025年11月14日

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  • Shogo Kitahata,
  • Mai Fukumoto,
  • Kana Matsuoka,
  • Takuya Matsuda,
  • Taisei Murakami,
  • Kei Onishi,
  • Hirofumi Izumoto,
  • Kozue Kanemitsu,
  • Tomoe Kawamura,
  • Taira Kuroda,
  • Junko Matsuoka,
  • Fujimasa Tada,
  • Hideki Miyata,
  • Atsushi Hiraoka,
  • Kazuhiro Tange,
  • Yasunori Yamamoto,
  • Eiji Takeshita,
  • Yoshiou Ikeda,
  • Shinya Furukawa,
  • Eiji Tsubouchi,
  • Tomoyuki Ninomiya,
  • Yoichi Hiasa

摘要

Background

Non-anemic iron deficiency is common in patients with ulcerative colitis; however, it may be underestimated and untreated, negatively impacting the quality of life. Therefore, this study aimed to investigate factors associated with non-anemic iron deficiency in Japanese patients with ulcerative colitis.

Methods

This cross-sectional study was conducted in Japan between April 2021 and March 2023. The study participants included 112 patients with ulcerative colitis without anemia. Iron deficiency was defined as ferritin levels < 100 and < 30 ng/mL in patients with disease activity (defined as Mayo endoscopic subscores ≥ 2) and those without disease activity, respectively.

Results

Patients with ulcerative colitis without anemia were classified as those with iron deficiency (n = 38) and normal iron status (n = 74). The prevalence of non-anemic iron deficiency was 33.9%. Multivariate analysis revealed that female sex (adjusted odds ratio: 15.40, 95% confidence interval: 2.66–89.00) and non-mucosal healing (adjusted odds ratio: 18.10, 95% confidence interval: 2.97–110.00) were independently associated with non-anemic iron deficiency. Conversely, clinical remission, the use of prednisolone, C-reactive protein level, and transferrin saturation level were not significantly associated with non-anemic iron deficiency.

Conclusion

Female sex and non-mucosal healing were identified as independent factors significantly associated with the prevalence of non-anemic iron deficiency in patients with ulcerative colitis. Therefore, monitoring of iron dynamics in patients with ulcerative colitis who have these characteristics is recommended even in the absence of anemia.

Graphical abstract