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Background <p>This study aimed to investigate whether the polyphenolic compound resveratrol can protect against intestinal injury induced by aspirin in hypoxic rats associated with the inhibition of angiotensin II (Ang-II), as well as mitigating intestinal mucosal oxidative stress and inflammation.</p> Method <p>The plain control group rats received daily gavage in a conventional atmosphere, while the high-altitude blank control group rats underwent the same procedure but was housed in a chamber simulating the hypoxic environment in a high-altitude.while the remaining groups rats were also housed in this hypoxic chamber and received daily aspirin gavage to establish an Aspirin-induced intestinal injury model. The resveratrol intervention group was administered resveratrol at varying doses 2&#xa0;h post-aspirin gavage. Small intestinal mucosal gross morphology and histopathological damage were observed and scored across all groups. ELISA quantified MPO and SOD activity and IL-1β, IL-10, TNF-α levels in intestinal tissues, while immunohistochemistry assessed Ang-II and Intercellular adhesion molecule-1 (ICAM-1) expression.</p> Result <p>The high-altitude blank control group rats not only showed substantial intestinal injuries but also exhibited elevated expression of Ang-II and ICAM-1 in the small intestinal tissues of rats, which positively correlated with the degree of histological injury to the mucosa. Furthermore, there was increased expression of pro-inflammatory factors IL-1β and TNF-α, decreased expression of the anti-inflammatory factor IL-10, and elevated levels of the oxidative stress indicator myeloperoxidase (MPO) activity, while the levels of superoxide dismutase (SOD) were decreased in the small intestinal tissues of rats. The administration of aspirin in the hypoxic environment exacerbated intestinal inflammation and damage to the intestinal mucosa. After treatment with Resveratrol intervention, the expression of Ang-II and ICAM-1 was reduced, while oxidative stress and inflammatory responses in the intestinal mucosa were also decreased. The results of HE staining directly demonstrated the damage to the intestines and the repair of the intestinal mucosa after Resveratrol intervention. The effect of medium-dose resveratrol appeared to be particularly pronounced.</p> Conclusion <p>Resveratrol can effectively mitigate intestinal injury induced by aspirin at high altitude in hypoxic environments. The mechanism may involve downregulating the expression of Ang-II and ICAM-1, alleviating oxidative stress and the inflammatory response of the intestinal mucosa, and preserving intestinal barrier function.</p>

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Resveratrol mitigates aspirin-induced intestinal injury in rats in a high-altitude hypoxic environment associated with reducing the expression levels of angiotensin II

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  • 发表日期：

    2025年8月27日

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  • Paziliya Abulaiti,
  • Wen Hui Shi,
  • Huan Liu,
  • Ailifeire Tuerxuntayi,
  • Kailibinuer Nuermaimaiti,
  • Zhuo Shuyi Liu,
  • Yingying Xing,
  • Najimangu Rehemutula,
  • Kudelaiti Abdukelimu,
  • Weidong Liu,
  • Jiang Wei Liu,
  • Feng Gao

摘要

Background

This study aimed to investigate whether the polyphenolic compound resveratrol can protect against intestinal injury induced by aspirin in hypoxic rats associated with the inhibition of angiotensin II (Ang-II), as well as mitigating intestinal mucosal oxidative stress and inflammation.

Method

The plain control group rats received daily gavage in a conventional atmosphere, while the high-altitude blank control group rats underwent the same procedure but was housed in a chamber simulating the hypoxic environment in a high-altitude.while the remaining groups rats were also housed in this hypoxic chamber and received daily aspirin gavage to establish an Aspirin-induced intestinal injury model. The resveratrol intervention group was administered resveratrol at varying doses 2 h post-aspirin gavage. Small intestinal mucosal gross morphology and histopathological damage were observed and scored across all groups. ELISA quantified MPO and SOD activity and IL-1β, IL-10, TNF-α levels in intestinal tissues, while immunohistochemistry assessed Ang-II and Intercellular adhesion molecule-1 (ICAM-1) expression.

Result

The high-altitude blank control group rats not only showed substantial intestinal injuries but also exhibited elevated expression of Ang-II and ICAM-1 in the small intestinal tissues of rats, which positively correlated with the degree of histological injury to the mucosa. Furthermore, there was increased expression of pro-inflammatory factors IL-1β and TNF-α, decreased expression of the anti-inflammatory factor IL-10, and elevated levels of the oxidative stress indicator myeloperoxidase (MPO) activity, while the levels of superoxide dismutase (SOD) were decreased in the small intestinal tissues of rats. The administration of aspirin in the hypoxic environment exacerbated intestinal inflammation and damage to the intestinal mucosa. After treatment with Resveratrol intervention, the expression of Ang-II and ICAM-1 was reduced, while oxidative stress and inflammatory responses in the intestinal mucosa were also decreased. The results of HE staining directly demonstrated the damage to the intestines and the repair of the intestinal mucosa after Resveratrol intervention. The effect of medium-dose resveratrol appeared to be particularly pronounced.

Conclusion

Resveratrol can effectively mitigate intestinal injury induced by aspirin at high altitude in hypoxic environments. The mechanism may involve downregulating the expression of Ang-II and ICAM-1, alleviating oxidative stress and the inflammatory response of the intestinal mucosa, and preserving intestinal barrier function.