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Objectives <p>Our objective was to compare the clinical features of Metabolic dysfunction-associated steatotic liver disease (MASLD) /metabolic alcohol-related liver disease (MetALD)/metabolic associated fatty liver disease (MAFLD)/nonalcoholic fatty liver disease (NAFLD) and the relative risk analysis of metabolic disorders.</p> Methods <p>The National Health and Nutrition Examination Survey for the 2017–2018 cycle was used to screen the participants. Multivariate-adjusted logistic regression models were applied to explore the difference in relative risk analysis between NAFLD/MAFLD/MASLD/MetALD and metabolic disorders.</p> Results <p>Among the 1,862 eligible individuals, 358(44.84%) had MASLD, 213(11.44%) had MetALD, 841(45.17%) had MAFLD, and 1,125(60.42%) had NAFLD. Positive associations with the risk of hypertension were discovered for MASLD (OR = 2.892, 95%CI = 2.226–3.756), MetALD (OR = 1.802, 95% CI = 1.355–2.398), MAFLD (OR = 3.455, 95%CI = 2.741–4.354) and NAFLD (OR = 1.983, 95%CI = 1.584–2.484). Positive associations with the risk of T2DM were discovered for MASLD (OR = 6.360, 95%CI = 4.440–9.109), MAFLD (OR = 7.026, 95%CI = 4.893–10.090) and NAFLD (OR = 3.372, 95%CI = 2.511–4.528). We discovered similar results for hyperlipidemia. Compared to mild steatosis, moderate to severe steatosis in patients with MASLD (OR = 3.924, 95%CI = 2.399–6.419), MAFLD (OR = 3.814, 95%CI = 2.367–6.144), NAFLD (OR = 4.910, 95%CI = 2.983–8.080) has a higher risk for T2DM.</p> Conclusion <p>The proposed definitions of MASLD and MetALD are valuable and deserve further exploration. Our findings suggest that MAFLD is a more effective indicator for identifying patients at increased risk for metabolic disorders.</p>

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Clinical characteristics of MASLD/MetALD/MAFLD/NAFLD and the relative risk analysis on metabolic disorders

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月14日

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  • Hong-ye Peng,
  • Chun-li Lu,
  • Mo Zhao,
  • Xiao-qiang Huang,
  • Shu-xia Huang,
  • Zi-wen Zhuo,
  • Jing Liu,
  • Yan-ping Lu,
  • Wen-liang Lv

摘要

Objectives

Our objective was to compare the clinical features of Metabolic dysfunction-associated steatotic liver disease (MASLD) /metabolic alcohol-related liver disease (MetALD)/metabolic associated fatty liver disease (MAFLD)/nonalcoholic fatty liver disease (NAFLD) and the relative risk analysis of metabolic disorders.

Methods

The National Health and Nutrition Examination Survey for the 2017–2018 cycle was used to screen the participants. Multivariate-adjusted logistic regression models were applied to explore the difference in relative risk analysis between NAFLD/MAFLD/MASLD/MetALD and metabolic disorders.

Results

Among the 1,862 eligible individuals, 358(44.84%) had MASLD, 213(11.44%) had MetALD, 841(45.17%) had MAFLD, and 1,125(60.42%) had NAFLD. Positive associations with the risk of hypertension were discovered for MASLD (OR = 2.892, 95%CI = 2.226–3.756), MetALD (OR = 1.802, 95% CI = 1.355–2.398), MAFLD (OR = 3.455, 95%CI = 2.741–4.354) and NAFLD (OR = 1.983, 95%CI = 1.584–2.484). Positive associations with the risk of T2DM were discovered for MASLD (OR = 6.360, 95%CI = 4.440–9.109), MAFLD (OR = 7.026, 95%CI = 4.893–10.090) and NAFLD (OR = 3.372, 95%CI = 2.511–4.528). We discovered similar results for hyperlipidemia. Compared to mild steatosis, moderate to severe steatosis in patients with MASLD (OR = 3.924, 95%CI = 2.399–6.419), MAFLD (OR = 3.814, 95%CI = 2.367–6.144), NAFLD (OR = 4.910, 95%CI = 2.983–8.080) has a higher risk for T2DM.

Conclusion

The proposed definitions of MASLD and MetALD are valuable and deserve further exploration. Our findings suggest that MAFLD is a more effective indicator for identifying patients at increased risk for metabolic disorders.