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Background <p>Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive. To investigate this association, this comprehensive meta-analysis was conducted.</p> Methods <p>A systematic electronic search was conducted using the PubMed, Embase, and Web of Science databases from their inception until July 2024 to identify observational studies assessing the relationship between TyG-WC and the risk of NAFLD. Joanna Briggs Institute’s critical appraisal checklist was utilized to evaluate the quality of cross-sectional studies, while the Newcastle-Ottawa Scale (NOS) score was used to assess cohort studies. The principal summary outcomes included the mean difference (MD) and the corresponding 95% confidence interval (CI).</p> Results <p>In total, 10 studies comprising 38,518 participants were included in this meta-analysis, of whom 37% were diagnosed with NAFLD. The analysis revealed a significant MD between NAFLD and non-NAFLD cases (MD, 137.41; [95% CI, 121.52-153.31]).</p> Conclusion <p>A significant MD was identified between NAFLD and non-NAFLD cases. The TyG-WC index was found to be positively correlated with the risk of NAFLD, suggesting that it may serve as a potential indicator for NAFLD.</p>

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Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月1日

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  • Ziyi Xin,
  • Lanlan Feng,
  • Qingwen Yu,
  • Yongmin Shi,
  • Ting Tang,
  • Xuhan Tong,
  • Siqi Hu,
  • Yao You,
  • Shenghui Zhang,
  • Xingwei Zhang,
  • Mingwei Wang,
  • Jiake Tang

摘要

Background

Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive. To investigate this association, this comprehensive meta-analysis was conducted.

Methods

A systematic electronic search was conducted using the PubMed, Embase, and Web of Science databases from their inception until July 2024 to identify observational studies assessing the relationship between TyG-WC and the risk of NAFLD. Joanna Briggs Institute’s critical appraisal checklist was utilized to evaluate the quality of cross-sectional studies, while the Newcastle-Ottawa Scale (NOS) score was used to assess cohort studies. The principal summary outcomes included the mean difference (MD) and the corresponding 95% confidence interval (CI).

Results

In total, 10 studies comprising 38,518 participants were included in this meta-analysis, of whom 37% were diagnosed with NAFLD. The analysis revealed a significant MD between NAFLD and non-NAFLD cases (MD, 137.41; [95% CI, 121.52-153.31]).

Conclusion

A significant MD was identified between NAFLD and non-NAFLD cases. The TyG-WC index was found to be positively correlated with the risk of NAFLD, suggesting that it may serve as a potential indicator for NAFLD.