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Introduction <p>Coronavirus disease (COVID-19) has been associated with thromboembolic and bleeding complications. Our study aims to understand the utility of early Thromboelastography (TEG) in the emergency department as a point-of-care test in predicting clinical outcomes.</p> Materials and methodology <p>A prospective observational study was conducted in the emergency medicine department (ED) during June 2021- May 2022 with inclusion criteria of all patients above 18 years who arrived at the ED and had a positive COVID-19 RT PCR test. Hematological investigation, including TEG, was sent. Patients were followed up for 28-day mortality, thrombotic and bleeding complications.</p> Results <p>A total of 166 patients were enrolled in the study. 46% of patients had critical COVID-19. TEG was abnormal in 45% of patients. Hypercoagulability was seen in 32% of patients. 28-day mortality in our study population was 32.3%. The most common thrombotic complications were stroke (4.2%), myocardial infarction (3.6%), pulmonary embolism (1.2%), and DVT (0.6%). Logistic regression analysis showed that patients who had hypocoagulable TEG had a higher 28-day mortality.</p> Conclusion <p>COVID-associated coagulopathy can be associated with both thrombotic (venous and arterial) and bleeding complications. Hypocoagulability on initial TEG has a 7.49 times increased risk of mortality. Hypocoagulable TEG indicates an early predictor for mortality. Early TEG can be an essential tool in managing COVID-associated coagulopathy.</p>

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Clinical utility of Thromboelastography in patients with COVID-19: a prospective observational study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月10日

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  • A. Deepak Sai,
  • Ravindra Prithvishree,
  • K. Nagesh Savan,
  • Mohan Ganesh,
  • Gupta Nitin,
  • Kishore Asish,
  • S. Nisarg,
  • Chaudhuri Souvik,
  • Paonam Bemma

摘要

Introduction

Coronavirus disease (COVID-19) has been associated with thromboembolic and bleeding complications. Our study aims to understand the utility of early Thromboelastography (TEG) in the emergency department as a point-of-care test in predicting clinical outcomes.

Materials and methodology

A prospective observational study was conducted in the emergency medicine department (ED) during June 2021- May 2022 with inclusion criteria of all patients above 18 years who arrived at the ED and had a positive COVID-19 RT PCR test. Hematological investigation, including TEG, was sent. Patients were followed up for 28-day mortality, thrombotic and bleeding complications.

Results

A total of 166 patients were enrolled in the study. 46% of patients had critical COVID-19. TEG was abnormal in 45% of patients. Hypercoagulability was seen in 32% of patients. 28-day mortality in our study population was 32.3%. The most common thrombotic complications were stroke (4.2%), myocardial infarction (3.6%), pulmonary embolism (1.2%), and DVT (0.6%). Logistic regression analysis showed that patients who had hypocoagulable TEG had a higher 28-day mortality.

Conclusion

COVID-associated coagulopathy can be associated with both thrombotic (venous and arterial) and bleeding complications. Hypocoagulability on initial TEG has a 7.49 times increased risk of mortality. Hypocoagulable TEG indicates an early predictor for mortality. Early TEG can be an essential tool in managing COVID-associated coagulopathy.