Objective <p>The purpose of this study is to investigate the trauma hospital preparedness in disasters of 2019.</p> Methods <p>A cross-sectional study was conducted in two qualitative and quantitative phases. Data were collected retrospectively in the quantitative part through census and in the qualitative part through semi-structured interviews. Quantitative and qualitative data were analyzed using descriptive statistics and content analysis, respectively.</p> Results <p>The Hazard of the trauma hospital in 2019 were divided into two categories: natural (floods) and man-made (floods, street riots, incidence of COVID-19). 93% of all hazards were attributed to the spread of COVID-19, 5.4% to disturbances and 1.6% to floods. In the quantitative part, from 227 extracted codes, two main themes were finally classified titled " Hospital’s functional experience in response " and “Challenges and functional corrective solutions “.</p> Conclusions <p>Due to the exhaustion of hospitals, the accident proneness of Iran and as well as insufficient attention to safety, it is essential that hospitals, especially trauma hospitals, have disaster preparedness plans. By using these comprehensive preparedness, managers can reduce the consequence of disasters and achieve proper preparation.</p>