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Background <p>To assess the predictive value of multimodal non-invasive ultrasound in detecting severe coronary artery stenosis (CAS) in patients with right coronary artery dominance.</p> Methods <p>This prospective observational study enrolled patients undergoing coronary angiography and non-invasive echocardiography at the Department of Cardiology, Luzhou People’s Hospital, between December 2021 and August 2023. Severe CAS (SCAS) was defined as CAS ≥ 75% based on angiographic results. Patients were categorized into the SCAS group and the NSCAS group (non-severe CAS).</p> Results <p>A total of 121 patients were included, with 98 in the NSCAS group and 23 in the SCAS group. Compared to the NSCAS group, the SCAS group showed a lower left ventricular ejection fraction (LVEF) (49.3 ± 9.8% vs. 58.9 ± 5.2%, <i>p</i> = 0.028), a higher left ventricular end-systolic diameter(LVsd) (35.2 ± 7.7&#xa0;mm vs. 29.8 ± 5.0&#xa0;mm, <i>p</i> = 0.020), and a higher end-systolic volume༈ESV༉ (54.0 ± 23.0&#xa0;ml vs. 35.7 ± 21.8&#xa0;ml, <i>p</i> = 0.041). According to the receiver operating characteristic curve analysis, the optimal cutoff values for predicting SCAS are as follows: motion score, 1.5; ESV, 47.5&#xa0;ml; LVsd, 30.5&#xa0;mm; LVEF, 53.5%; mitral annular systolic velocity༈Smv༉, 8.5&#xa0;cm/s; and global longitudinal peak strain༈GLPS༉, -16.5% (all <i>p</i> &lt; 0.05). Multivariate logistic regression showed that LVEF was associated with SCAS (OR = 1.600, 95% CI:1.037–2.468, <i>P</i> = 0.034).</p> Conclusions <p>Our findings suggest that LVEF may play a role in predicting SCAS, validating non-invasive ultrasound as an effective early diagnostic tool for patients with right coronary artery dominance.</p> Trial registration <p>Not applicable.</p>

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Multimodal non-invasive ultrasound for predicting severe coronary artery stenosis in right coronary dominant patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月28日

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  • Kedan Hu,
  • Qinghong Liu,
  • Chunyan Li,
  • Linru Zheng,
  • Ling Luo,
  • Ming Gao

摘要

Background

To assess the predictive value of multimodal non-invasive ultrasound in detecting severe coronary artery stenosis (CAS) in patients with right coronary artery dominance.

Methods

This prospective observational study enrolled patients undergoing coronary angiography and non-invasive echocardiography at the Department of Cardiology, Luzhou People’s Hospital, between December 2021 and August 2023. Severe CAS (SCAS) was defined as CAS ≥ 75% based on angiographic results. Patients were categorized into the SCAS group and the NSCAS group (non-severe CAS).

Results

A total of 121 patients were included, with 98 in the NSCAS group and 23 in the SCAS group. Compared to the NSCAS group, the SCAS group showed a lower left ventricular ejection fraction (LVEF) (49.3 ± 9.8% vs. 58.9 ± 5.2%, p = 0.028), a higher left ventricular end-systolic diameter(LVsd) (35.2 ± 7.7 mm vs. 29.8 ± 5.0 mm, p = 0.020), and a higher end-systolic volume༈ESV༉ (54.0 ± 23.0 ml vs. 35.7 ± 21.8 ml, p = 0.041). According to the receiver operating characteristic curve analysis, the optimal cutoff values for predicting SCAS are as follows: motion score, 1.5; ESV, 47.5 ml; LVsd, 30.5 mm; LVEF, 53.5%; mitral annular systolic velocity༈Smv༉, 8.5 cm/s; and global longitudinal peak strain༈GLPS༉, -16.5% (all p < 0.05). Multivariate logistic regression showed that LVEF was associated with SCAS (OR = 1.600, 95% CI:1.037–2.468, P = 0.034).

Conclusions

Our findings suggest that LVEF may play a role in predicting SCAS, validating non-invasive ultrasound as an effective early diagnostic tool for patients with right coronary artery dominance.

Trial registration

Not applicable.