Scholarlink

Background <p>Acute myocardial infarction (AMI) in critically ill patients is associated with high mortality. The glucose-to-platelet ratio (GPR), derived from routine early glucose and platelet measurements, may provide additional prognostic information, but its value in ICU patients with AMI remains unclear.</p> Methods <p>This retrospective cohort study included 4,676 adult ICU patients with AMI from the MIMIC-IV version 3.1 database. GPR was calculated as the mean glucose concentration during the first 24&#xa0;h after ICU admission divided by the first platelet count recorded within the same period. Outcomes were 30-day and 360-day all-cause mortality from ICU admission. Associations were assessed using multivariable Cox proportional hazards models, restricted cubic splines, and exploratory internally validated prediction models.</p> Results <p>Among 4,676 patients, the 30-day and 360-day mortality rates were 19.6% and 29.1%, respectively. In the fully adjusted model, each 1-unit increase in GPR was associated with higher 30-day mortality (HR, 1.10; 95% CI, 1.05–1.15) and 360-day mortality (HR, 1.12; 95% CI, 1.07–1.16; both <i>P</i> &lt; 0.001). Compared with the lowest tertile, the highest GPR tertile was associated with increased 30-day mortality (HR, 1.60; 95% CI, 1.35–1.90) and 360-day mortality (HR, 1.29; 95% CI, 1.12–1.47; both <i>P</i> &lt; 0.001). Spline analyses suggested nonlinearity only for 30-day mortality. In exploratory internal validation, ridge regression incorporating GPR achieved an area under the receiver operating characteristic curve of 0.816.</p> Conclusions <p>Higher GPR was independently associated with increased short- and long-term all-cause mortality in critically ill patients with AMI. GPR may complement conventional variables for early ICU risk stratification.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between glucose-to-platelet ratio and all-cause mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月4日

查看全文
  • Xingzhan Zhang,
  • Dakai Liang,
  • Xia Luo,
  • Ling Zhao,
  • Jie Peng

摘要

Background

Acute myocardial infarction (AMI) in critically ill patients is associated with high mortality. The glucose-to-platelet ratio (GPR), derived from routine early glucose and platelet measurements, may provide additional prognostic information, but its value in ICU patients with AMI remains unclear.

Methods

This retrospective cohort study included 4,676 adult ICU patients with AMI from the MIMIC-IV version 3.1 database. GPR was calculated as the mean glucose concentration during the first 24 h after ICU admission divided by the first platelet count recorded within the same period. Outcomes were 30-day and 360-day all-cause mortality from ICU admission. Associations were assessed using multivariable Cox proportional hazards models, restricted cubic splines, and exploratory internally validated prediction models.

Results

Among 4,676 patients, the 30-day and 360-day mortality rates were 19.6% and 29.1%, respectively. In the fully adjusted model, each 1-unit increase in GPR was associated with higher 30-day mortality (HR, 1.10; 95% CI, 1.05–1.15) and 360-day mortality (HR, 1.12; 95% CI, 1.07–1.16; both P < 0.001). Compared with the lowest tertile, the highest GPR tertile was associated with increased 30-day mortality (HR, 1.60; 95% CI, 1.35–1.90) and 360-day mortality (HR, 1.29; 95% CI, 1.12–1.47; both P < 0.001). Spline analyses suggested nonlinearity only for 30-day mortality. In exploratory internal validation, ridge regression incorporating GPR achieved an area under the receiver operating characteristic curve of 0.816.

Conclusions

Higher GPR was independently associated with increased short- and long-term all-cause mortality in critically ill patients with AMI. GPR may complement conventional variables for early ICU risk stratification.