Scholarlink

Background <p>Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of cardiovascular mortality worldwide, with insulin resistance recognized as a key pathophysiological driver. While the triglyceride glucose-body mass index (TyG-BMI) has emerged as a promising insulin resistance marker, its prognostic value for ASCVD mortality outcomes requires further elucidation.</p> Methods <p>We conducted a retrospective cohort study of 1,637 critically ill ASCVD patients (median age 68.3 years) from the MIMIC-IV database. The primary endpoints were 30-day and 1-year mortality, with secondary assessments of 90-day and 180-day mortality. Comprehensive statistical analyses included multivariable Cox regression, restricted cubic splines (RCSs) for nonlinearity assessment, and Kaplan-Meier survival analysis.</p> Results <p>After full adjustment for potential confounders, elevated TyG-BMI showed significant inverse associations with both 30-day (HR 0.11, 95% CI 0.06–0.19) and 1-year mortality (HR 0.13, 95% CI 0.08–0.20). RCS analysis revealed a characteristic L-shaped dose-response relationship (nonlinear <i>P</i> &lt; 0.001), while Kaplan-Meier curves demonstrated progressively improved survival across TyG-BMI quartiles (log-rank <i>P</i> &lt; 0.001).</p> Conclusion <p>This study revealed that the TyG-BMI is an independent predictor of mortality in critically ill ASCVD patients, with a distinct nonlinear protective effect. These findings support the potential clinical utility of the TyG-BMI for risk stratification in this high-risk population.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases: a retrospective cohort study using the MIMIC-IV database

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月29日

查看全文
  • Yaxin Liu,
  • Chenxi Fu,
  • Fengao Li,
  • Hao Wang,
  • Mei Zhu

摘要

Background

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of cardiovascular mortality worldwide, with insulin resistance recognized as a key pathophysiological driver. While the triglyceride glucose-body mass index (TyG-BMI) has emerged as a promising insulin resistance marker, its prognostic value for ASCVD mortality outcomes requires further elucidation.

Methods

We conducted a retrospective cohort study of 1,637 critically ill ASCVD patients (median age 68.3 years) from the MIMIC-IV database. The primary endpoints were 30-day and 1-year mortality, with secondary assessments of 90-day and 180-day mortality. Comprehensive statistical analyses included multivariable Cox regression, restricted cubic splines (RCSs) for nonlinearity assessment, and Kaplan-Meier survival analysis.

Results

After full adjustment for potential confounders, elevated TyG-BMI showed significant inverse associations with both 30-day (HR 0.11, 95% CI 0.06–0.19) and 1-year mortality (HR 0.13, 95% CI 0.08–0.20). RCS analysis revealed a characteristic L-shaped dose-response relationship (nonlinear P < 0.001), while Kaplan-Meier curves demonstrated progressively improved survival across TyG-BMI quartiles (log-rank P < 0.001).

Conclusion

This study revealed that the TyG-BMI is an independent predictor of mortality in critically ill ASCVD patients, with a distinct nonlinear protective effect. These findings support the potential clinical utility of the TyG-BMI for risk stratification in this high-risk population.