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<p>A 78-year-old female developed symptomatic bioprosthetic valve thrombosis 32 months post-transapical TAVI, despite 6-month warfarin therapy. Echocardiography showed severe hemodynamic compromise with left ventricular remodeling and diastolic dysfunction. CT-confirmed thrombosis resolved after warfarin intensification and cardiac optimization, achieving mean gradient reduction to 17 mmHg within 8 weeks. This highlights the association between delayed thrombosis, ventricular remodeling, and subtherapeutic anticoagulation.</p>

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Delayed bioprosthetic valve thrombosis after transcatheter aortic valve implantation in a patient with severe left ventricular diastolic dysfunction: A case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月21日

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  • Shuai Yuan,
  • Jing Li,
  • Yun Mou,
  • Yiming Ni

摘要

A 78-year-old female developed symptomatic bioprosthetic valve thrombosis 32 months post-transapical TAVI, despite 6-month warfarin therapy. Echocardiography showed severe hemodynamic compromise with left ventricular remodeling and diastolic dysfunction. CT-confirmed thrombosis resolved after warfarin intensification and cardiac optimization, achieving mean gradient reduction to 17 mmHg within 8 weeks. This highlights the association between delayed thrombosis, ventricular remodeling, and subtherapeutic anticoagulation.