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Objective <p>To investigate the association between serum sodium levels within 24 hours of admission and short-term (28-day) and medium-term (1-year) all-cause mortality in patients with ST-segment elevation myocardial infarction (STEMI) following emergency percutaneous coronary intervention (PCI).</p> Methods <p>We conducted a single-center retrospective cohort study including 532 patients with STEMI who underwent emergency PCI from January 2020 to January 2022. Patients were stratified into two groups based on admission serum sodium levels: &lt;145 mmol/L (n=476) and ≥145 mmol/L (n=56). Restricted cubic spline models analyzed the non-linear relationship, and multivariable logistic regression assessed prognostic impact. </p> Results <p>All-cause mortality rates were 2.2% (12/532) at 28 days and 2.8% (15/532) at 1 year. Restricted cubic spline analysis revealed a U-shaped association between serum sodium and mortality (<i>P</i> &lt; 0.001), with an inflection point at 143 mmol/L. Subgroup analyses confirmed stability across age, gender, and comorbidities. </p> Conclusions <p>Admission hypernatremia (≥145 mmol/L) is significantly associated with increased 28-day and 1-year mortality risks in STEMI patients post-emergency PCI. Early sodium management may improve outcomes.</p>

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Correlation of admission sodium levels with 28-Day and 1-year mortality in STEMI patients undergoing emergency PCI

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月10日

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  • Qingqing Ruan,
  • Zengyong Qiao,
  • Xiumei Li

摘要

Objective

To investigate the association between serum sodium levels within 24 hours of admission and short-term (28-day) and medium-term (1-year) all-cause mortality in patients with ST-segment elevation myocardial infarction (STEMI) following emergency percutaneous coronary intervention (PCI).

Methods

We conducted a single-center retrospective cohort study including 532 patients with STEMI who underwent emergency PCI from January 2020 to January 2022. Patients were stratified into two groups based on admission serum sodium levels: <145 mmol/L (n=476) and ≥145 mmol/L (n=56). Restricted cubic spline models analyzed the non-linear relationship, and multivariable logistic regression assessed prognostic impact.

Results

All-cause mortality rates were 2.2% (12/532) at 28 days and 2.8% (15/532) at 1 year. Restricted cubic spline analysis revealed a U-shaped association between serum sodium and mortality (P < 0.001), with an inflection point at 143 mmol/L. Subgroup analyses confirmed stability across age, gender, and comorbidities.

Conclusions

Admission hypernatremia (≥145 mmol/L) is significantly associated with increased 28-day and 1-year mortality risks in STEMI patients post-emergency PCI. Early sodium management may improve outcomes.