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Objectives <p>To investigate the association of Procollagen I N-Terminal Propeptide (PINP) with myocardial fibrosis (MF) and its predictive effect on major adverse cardiovascular events (MACEs) in patients with primary diagnosis of heart failure (HF).</p> Methods <p>A total of 76 newly diagnosed HF patients with reduced ejection fraction were followed up for one year. Serum PINP levels and extracellular volumes (ECV) quantified by cardiac magnetic resonance(CMR) imaging at baseline were collected. MF was defined when a ECV value was greater than 28.5%. The first MACEs defined as rehospitalization and/or cardiovascular death, were recorded during the visit.</p> Results <p>The levels of PINP in patients with MF were higher than those in patients without MF (39.90 VS 49.10 ng/ml, <i>P</i> = 0.030). Multivariate logistic regression analysis showed that PINP was an independent risk factor for MF (OR 1.058, 95% CI 1.018 ~ 1.098, <i>P</i> = 0.004). The linear regression model showed a linear correlation between the PINP levels and ECVs (<i>R</i> = 0.280, <i>P</i> = 0.014). Patients with higher PINP levels had a significant increased risk of incident MACE than those with lower PINP levels (HR 1.95, 95%CI 1.03 ~ 3.69, <i>P</i> = 0.033).</p> Conclusion <p>In patients with newly diagnosed HF, serum PINP levels were associated with MF and an increased risk of MACEs during a one-year follow-up.</p>

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PINP levels in patients with newly diagnosed heart failure are associated with myocardial fibrosis and clinical outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月13日

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  • Mengjie Liu,
  • Hailang Liu,
  • Qiuyao Du,
  • Shiyu Lei,
  • Tingting Hu,
  • Jin Geng,
  • Qing Zhang

摘要

Objectives

To investigate the association of Procollagen I N-Terminal Propeptide (PINP) with myocardial fibrosis (MF) and its predictive effect on major adverse cardiovascular events (MACEs) in patients with primary diagnosis of heart failure (HF).

Methods

A total of 76 newly diagnosed HF patients with reduced ejection fraction were followed up for one year. Serum PINP levels and extracellular volumes (ECV) quantified by cardiac magnetic resonance(CMR) imaging at baseline were collected. MF was defined when a ECV value was greater than 28.5%. The first MACEs defined as rehospitalization and/or cardiovascular death, were recorded during the visit.

Results

The levels of PINP in patients with MF were higher than those in patients without MF (39.90 VS 49.10 ng/ml, P = 0.030). Multivariate logistic regression analysis showed that PINP was an independent risk factor for MF (OR 1.058, 95% CI 1.018 ~ 1.098, P = 0.004). The linear regression model showed a linear correlation between the PINP levels and ECVs (R = 0.280, P = 0.014). Patients with higher PINP levels had a significant increased risk of incident MACE than those with lower PINP levels (HR 1.95, 95%CI 1.03 ~ 3.69, P = 0.033).

Conclusion

In patients with newly diagnosed HF, serum PINP levels were associated with MF and an increased risk of MACEs during a one-year follow-up.