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Background and objective <p>Abdominal aortic aneurysm (AAA) poses a significant health risk, particularly in aging populations. This study aims to quantify the association between Helicobacter pylori (H. pylori) infection and AAA development through a systematic review and meta-analysis, emphasizing numerical results for clarity.</p> Method <p>Following PRISMA guidelines, PubMed, SCOPUS, Medline and Embase searches were conducted. Data extraction and quality assessment were performed using standardized tools. Statistical analysis involved calculating a pooled risk ratio (RR) with a 95% confidence interval (CI) to determine the association between H. pylori infection and AAA development.</p> Result <p>Among the 8 selected studies, H. pylori infection exhibited a statistically significant overall RR of 1.54 (95% CI: 1.14–2.08, <i>P</i> = 0.005) for AAA development. Subgroup and sensitivity analyses were conducted to address high heterogeneity, revealing consistent results. The event rate analysis across studies showed an overall rate of 41%, (95% CI: 0.293 to 0.547) with significant variability observed among individual study populations.</p> Conclusion <p>The meta-analysis confirms a significant association between H. pylori infection and AAA development, with an elevated risk ratio of 1.54. These findings underscore the importance of further research to elucidate underlying mechanisms and inform preventive strategies and interventions aimed at mitigating the risk of AAA in individuals with H. pylori infection.</p>

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Association between helicobacter pylori infection and abdominal aortic aneurysm: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月26日

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  • Mustafa Arain,
  • Jahnavi Karnatapu,
  • Iman Moradi,
  • Lesly Bailon Cevallos,
  • Phanish Chandra Ravi,
  • Pradeep Valluri,
  • Asees Lubana,
  • Aleena Maryam,
  • Amirhossein Moradi,
  • Anil Kumar Yennam,
  • Bojanki Naga Venkata Lova Surya Vamsi Avinash,
  • Zorez Rashid Mian,
  • Saif Syed,
  • Behrooz Shojai Rahnama,
  • Khabab Abbasher Hussien Mohamed Ahmed,
  • Muhammad Ashir Shafique

摘要

Background and objective

Abdominal aortic aneurysm (AAA) poses a significant health risk, particularly in aging populations. This study aims to quantify the association between Helicobacter pylori (H. pylori) infection and AAA development through a systematic review and meta-analysis, emphasizing numerical results for clarity.

Method

Following PRISMA guidelines, PubMed, SCOPUS, Medline and Embase searches were conducted. Data extraction and quality assessment were performed using standardized tools. Statistical analysis involved calculating a pooled risk ratio (RR) with a 95% confidence interval (CI) to determine the association between H. pylori infection and AAA development.

Result

Among the 8 selected studies, H. pylori infection exhibited a statistically significant overall RR of 1.54 (95% CI: 1.14–2.08, P = 0.005) for AAA development. Subgroup and sensitivity analyses were conducted to address high heterogeneity, revealing consistent results. The event rate analysis across studies showed an overall rate of 41%, (95% CI: 0.293 to 0.547) with significant variability observed among individual study populations.

Conclusion

The meta-analysis confirms a significant association between H. pylori infection and AAA development, with an elevated risk ratio of 1.54. These findings underscore the importance of further research to elucidate underlying mechanisms and inform preventive strategies and interventions aimed at mitigating the risk of AAA in individuals with H. pylori infection.