Backgrounds <p>This study aimed to evaluate the prevalence and determinants of hyperuricemia in patients with newly-diagnosed coronary artery disease (CAD) after percutaneous coronary intervention.</p> Methods <p>Hyperuricemia was defined as a serum urate level of &gt; 5.6&#xa0;mg/dl. Medical records and face-to-face interviews were used to collect the demographic characteristics, medical history, lifestyle, self-management, physical examination, and laboratory examination information for each patient. Logistic regression was then used to assess the associations between hyperuricemia and several independent risk factors.</p> Results <p>The regression results showed that the overall prevalence of hyperuricemia was 43.2% (42.0% in men and 47.0% in women) and gender, hypertension, triglycerides, body mass index (BMI) and HbA1c were risk factors for hyperuricemia.</p> Conclusions <p>Our findings suggest that the prevalence of hyperuricemia is very high in newly-diagnosed CAD patients after percutaneous coronary intervention (PCI), but the associated risk factors we identified can be ameliorated by diet and lifestyle changes.</p>