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Background <p>Depression and anxiety are common psychological disorders following acute coronary syndrome (ACS), potentially affecting patient outcomes. Sex-based disparities in the prevalence of these disorders may significantly impact recovery and rehabilitation post-ACS.</p> Aims <p>To evaluate gender-based differences in depression and anxiety prevalence among Turkish patients following (ACS), and to identify sociodemographic and clinical factors associated with psychological distress.</p> Methods <p>In this cross-sectional observational study, 604 patients (144 women and 460 men) diagnosed with ACS were enrolled at their initial outpatient follow-up (4–8 weeks post-discharge). Data collection included demographic and clinical surveys along with the Hospital Anxiety and Depression Scale (HADS).</p> Results <p>Depression and anxiety were significantly more prevalent in women than men (61.1% vs. 37.4% for depression, <i>p</i> &lt; 0.001; 30.6% vs. 20.0% for anxiety, <i>p</i> = 0.008). Moderate-to-severe symptoms were also more common among women for both conditions (<i>p</i> &lt; 0.001). Lower education levels and income below expenses were associated with higher anxiety and depression scores (<i>p</i> &lt; 0.025). Among women, married individuals reported higher anxiety than widowed/divorced women (<i>p</i> &lt; 0.001). Hypertension significantly increased distress, particularly in men (<i>p</i> &lt; 0.001), while chronic kidney disease had a stronger impact among women (<i>p</i> &lt; 0.018).</p> Conclusion <p>There are marked gender disparities in depression and anxiety prevalence post-ACS, with women being significantly more affected. Socioeconomic disadvantages and comorbid conditions contribute to psychological distress. Routine psychological screening and sex-sensitive interventions, especially for vulnerable groups, are crucial for improving outcomes after ACS. Significant gender disparities exist in post-ACS depression and anxiety, with women disproportionately affected. Socioeconomic disadvantage and comorbidities further compound psychological distress. Integrating routine mental health screening and sex-sensitive interventions into post-ACS care is essential, particularly for high-risk populations, to improve long-term outcomes.</p> Graphical Abstract <p></p>

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Gender-based distribution of depression and anxiety following acute coronary syndrome in the Turkish population: are women at higher risk?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月9日

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  • Ömer Kertmen,
  • Metin Çoksevim,
  • Abdülkadir Çakmak,
  • Tuğba Kertmen,
  • Doğan İliş

摘要

Background

Depression and anxiety are common psychological disorders following acute coronary syndrome (ACS), potentially affecting patient outcomes. Sex-based disparities in the prevalence of these disorders may significantly impact recovery and rehabilitation post-ACS.

Aims

To evaluate gender-based differences in depression and anxiety prevalence among Turkish patients following (ACS), and to identify sociodemographic and clinical factors associated with psychological distress.

Methods

In this cross-sectional observational study, 604 patients (144 women and 460 men) diagnosed with ACS were enrolled at their initial outpatient follow-up (4–8 weeks post-discharge). Data collection included demographic and clinical surveys along with the Hospital Anxiety and Depression Scale (HADS).

Results

Depression and anxiety were significantly more prevalent in women than men (61.1% vs. 37.4% for depression, p < 0.001; 30.6% vs. 20.0% for anxiety, p = 0.008). Moderate-to-severe symptoms were also more common among women for both conditions (p < 0.001). Lower education levels and income below expenses were associated with higher anxiety and depression scores (p < 0.025). Among women, married individuals reported higher anxiety than widowed/divorced women (p < 0.001). Hypertension significantly increased distress, particularly in men (p < 0.001), while chronic kidney disease had a stronger impact among women (p < 0.018).

Conclusion

There are marked gender disparities in depression and anxiety prevalence post-ACS, with women being significantly more affected. Socioeconomic disadvantages and comorbid conditions contribute to psychological distress. Routine psychological screening and sex-sensitive interventions, especially for vulnerable groups, are crucial for improving outcomes after ACS. Significant gender disparities exist in post-ACS depression and anxiety, with women disproportionately affected. Socioeconomic disadvantage and comorbidities further compound psychological distress. Integrating routine mental health screening and sex-sensitive interventions into post-ACS care is essential, particularly for high-risk populations, to improve long-term outcomes.

Graphical Abstract