Scholarlink

Background <p>This cross-sectional survey investigated the incidence of H-type hypertension and associated risk factors in a health checkup population in Urumqi, China. We aimed to identify potential intervention targets by screening patients with H-type hypertension and high-risk populations, filling the gap in the risk assessment of H-type hypertension in high-altitude areas.</p> Methods <p>From January 2023 to January 2024, we conducted a cross-sectional study on 1,772 individuals who underwent methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism evaluations. We included a questionnaire survey and collected physical measurements and blood samples. The relative risk factors related to H-type hypertension, as well as their correlation with the MTHFR C677T genotype, were subsequently analyzed.</p> Results <p>H-type hypertension was present in 68.96% of hypertension cases and 17.55% of the population in Urumqi who underwent health checkups. The methylenetetrahydrofolate reductase (MTHFR) C677T distributions of the CC, CT, and TT genotypes were 11.90%, 39.87%, and 48.23%, respectively. Moreover, multivariate logistic regression identified the MTHFR C677T TT genotype, age, triglyceride-glucose index (TyG), and carotid plaques as risk factors related to H-type hypertension, with odds ratios (ORs) of 3.044 (<i>p</i> &lt; 0.001), 1.041 (<i>p =</i> 0.001), 1.385 (<i>p =</i> 0.003), and 1.748 (<i>p</i> &lt; 0.001), respectively. In addition, high-density lipoprotein (HDL) cholesterol was identified as a protective factor (OR = 0.447, <i>p =</i> 0.002). Through regression analysis, a nomogram model was constructed to predict the incidence of H-type hypertension. This model showed a good fit, and the area under the receiver operating characteristic (ROC) curve (AUC) was 0.760. Its predicted H-type hypertension incidence was closely related to the actual incidence.</p> Conclusions <p>According to our findings, the MTHFR C677T TT genotype in Urumqi, China, serves as a risk locus related to H-type hypertension. Moreover, age, TyG, and carotid plaques are risk factors for H-type hypertension, whereas HDL is a protective factor.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月3日

查看全文
  • Na Li,
  • Xiaoping Yang,
  • Yuan Zou,
  • Jing Chen,
  • Yajing Cui,
  • Yunjie Teng,
  • Dan Yang,
  • Ayipali Aikemujiang,
  • Jianrong Wu

摘要

Background

This cross-sectional survey investigated the incidence of H-type hypertension and associated risk factors in a health checkup population in Urumqi, China. We aimed to identify potential intervention targets by screening patients with H-type hypertension and high-risk populations, filling the gap in the risk assessment of H-type hypertension in high-altitude areas.

Methods

From January 2023 to January 2024, we conducted a cross-sectional study on 1,772 individuals who underwent methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism evaluations. We included a questionnaire survey and collected physical measurements and blood samples. The relative risk factors related to H-type hypertension, as well as their correlation with the MTHFR C677T genotype, were subsequently analyzed.

Results

H-type hypertension was present in 68.96% of hypertension cases and 17.55% of the population in Urumqi who underwent health checkups. The methylenetetrahydrofolate reductase (MTHFR) C677T distributions of the CC, CT, and TT genotypes were 11.90%, 39.87%, and 48.23%, respectively. Moreover, multivariate logistic regression identified the MTHFR C677T TT genotype, age, triglyceride-glucose index (TyG), and carotid plaques as risk factors related to H-type hypertension, with odds ratios (ORs) of 3.044 (p < 0.001), 1.041 (p = 0.001), 1.385 (p = 0.003), and 1.748 (p < 0.001), respectively. In addition, high-density lipoprotein (HDL) cholesterol was identified as a protective factor (OR = 0.447, p = 0.002). Through regression analysis, a nomogram model was constructed to predict the incidence of H-type hypertension. This model showed a good fit, and the area under the receiver operating characteristic (ROC) curve (AUC) was 0.760. Its predicted H-type hypertension incidence was closely related to the actual incidence.

Conclusions

According to our findings, the MTHFR C677T TT genotype in Urumqi, China, serves as a risk locus related to H-type hypertension. Moreover, age, TyG, and carotid plaques are risk factors for H-type hypertension, whereas HDL is a protective factor.