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Background <p>The Naples prognostic score (NPS) evaluates the body’s systemic inflammatory and metabolic status. However, its relevance for patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI) is uncertain.</p> Methods <p>This study involved 1,485 diabetes patients following PCI from 2019 to 2023. Participants were divided into two groups based on their NPS. The primary endpoint was major adverse cardiovascular events (MACE). Secondary endpoints included components of MACE [all-cause mortality, recurrent myocardial infarction (MI), target vessel revascularization (TVR)], as well as cardiac death and stroke.</p> Results <p>The novel NPS model demonstrated greater predictive capacity for cardiac death in comparison to the conventional diabetes risk score (AUC: 0.711 vs. 0.560, ∆AUC: +0.151, <i>P</i> = 0.044).The NPS model exhibited comparable predictive power to the GRACE score with respect to MACE events, with the difference proving to be statistically non-significant (∆AUC: -0.002, <i>P</i> = 0.940). Kaplan-Meier analysis revealed higher incidences of MACE (8.0% vs. 3.6%, <i>P</i> &lt; 0.001), all-cause mortality (4.1% vs. 1.0%, <i>P</i> &lt; 0.001), cardiac death (2.9% vs. 0.4%, <i>P</i> &lt; 0.001), and stroke (4.1% vs. 2.2%, <i>P</i> = 0.035) in the high-risk NPS group compared to the low-risk group. Multivariate analysis identified high-risk NPS as an independent predictor of MACE (HR: 2.34; 95% CI: 1.50–3.67; <i>P</i> &lt; 0.001), all-cause mortality (HR: 4.20; 95% CI: 1.95–9.04; <i>P</i> &lt; 0.001), and cardiac death (HR: 6.68; 95% CI: 2.25–19.85; <i>P</i> &lt; 0.001). These associations remained significant after adjusting for multiple risk factors.</p> Conclusion <p>High-risk NPS correlates with a higher incidence of cardiovascular events in diabetic patients following PCI. Additionally, NPS is a more reliable predictor of survival outcomes than other inflammatory and metabolic indicators.</p> Clinical trial number <p>Not applicable.</p>

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Predicting the prognosis of diabetic patients undergoing percutaneous coronary intervention: the value of the Naples prognostic score in a real-world clinical study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月2日

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  • Mengzhu Zhou,
  • Xue Zhang,
  • Xiaohua Guo,
  • Junying Duan,
  • Haifeng Zhang,
  • Xing Liu,
  • Tong Liu,
  • Kangyin Chen,
  • Changle Liu

摘要

Background

The Naples prognostic score (NPS) evaluates the body’s systemic inflammatory and metabolic status. However, its relevance for patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI) is uncertain.

Methods

This study involved 1,485 diabetes patients following PCI from 2019 to 2023. Participants were divided into two groups based on their NPS. The primary endpoint was major adverse cardiovascular events (MACE). Secondary endpoints included components of MACE [all-cause mortality, recurrent myocardial infarction (MI), target vessel revascularization (TVR)], as well as cardiac death and stroke.

Results

The novel NPS model demonstrated greater predictive capacity for cardiac death in comparison to the conventional diabetes risk score (AUC: 0.711 vs. 0.560, ∆AUC: +0.151, P = 0.044).The NPS model exhibited comparable predictive power to the GRACE score with respect to MACE events, with the difference proving to be statistically non-significant (∆AUC: -0.002, P = 0.940). Kaplan-Meier analysis revealed higher incidences of MACE (8.0% vs. 3.6%, P < 0.001), all-cause mortality (4.1% vs. 1.0%, P < 0.001), cardiac death (2.9% vs. 0.4%, P < 0.001), and stroke (4.1% vs. 2.2%, P = 0.035) in the high-risk NPS group compared to the low-risk group. Multivariate analysis identified high-risk NPS as an independent predictor of MACE (HR: 2.34; 95% CI: 1.50–3.67; P < 0.001), all-cause mortality (HR: 4.20; 95% CI: 1.95–9.04; P < 0.001), and cardiac death (HR: 6.68; 95% CI: 2.25–19.85; P < 0.001). These associations remained significant after adjusting for multiple risk factors.

Conclusion

High-risk NPS correlates with a higher incidence of cardiovascular events in diabetic patients following PCI. Additionally, NPS is a more reliable predictor of survival outcomes than other inflammatory and metabolic indicators.

Clinical trial number

Not applicable.