Scholarlink

Objective <p>Arteriosclerosis plays a significant role as one of the key pathological mechanisms underlying Diabetic Kidney Disease (DKD). The estimated Pulse Wave Velocity (ePWV) is used to assess arteriosclerosis, and is considered a potential clinical surrogate for pulse wave velocity. There are no studies on ePWV in relation to DKD. Our research represents the first embark to explore the relationship between ePWV and DKD.</p> Methods <p>In this cross-sectional analysis, we collected ePWV data from a cohort of 4,296 hospitalized Chinese patients. Multivariable-adjusted logistic regression models and restricted cubic spline (RCS) analysis were employed to examine the relationship between eGDR and the prevalence of DKD, UACR ≥ 30&#xa0;mg/g, and eGFR &lt; 60 mL/min per 1.73&#xa0;m².</p> Results <p>After adjusting for confounding factors, each unit increase in ePWV was associated with a 23%, 21% and 25% increase in the prevalence of DKD, UACR ≥ 30&#xa0;mg/g, and eGFR &lt; 60 mL/min per 1.73&#xa0;m² in T2DM participants, respectively. A J-shaped relationship was observed between ePWV and the prevalence of DKD and eGFR &lt; 60 mL/min per 1.73&#xa0;m², and a linear association between ePWV and the prevalence of UACR ≥ 30&#xa0;mg/g.</p> Conclusion <p>ePWV is independently positively correlated with the prevalence of DKD. Integrating ePWV into routine clinical evaluations enable timely interventions and personalized management approaches.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The unique association between estimated pulse wave velocity and the prevalence of diabetic kidney disease: a cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月23日

查看全文
  • Shuwu Wei,
  • Xinyu Pan,
  • Yao Xiao,
  • Junping Wei

摘要

Objective

Arteriosclerosis plays a significant role as one of the key pathological mechanisms underlying Diabetic Kidney Disease (DKD). The estimated Pulse Wave Velocity (ePWV) is used to assess arteriosclerosis, and is considered a potential clinical surrogate for pulse wave velocity. There are no studies on ePWV in relation to DKD. Our research represents the first embark to explore the relationship between ePWV and DKD.

Methods

In this cross-sectional analysis, we collected ePWV data from a cohort of 4,296 hospitalized Chinese patients. Multivariable-adjusted logistic regression models and restricted cubic spline (RCS) analysis were employed to examine the relationship between eGDR and the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m².

Results

After adjusting for confounding factors, each unit increase in ePWV was associated with a 23%, 21% and 25% increase in the prevalence of DKD, UACR ≥ 30 mg/g, and eGFR < 60 mL/min per 1.73 m² in T2DM participants, respectively. A J-shaped relationship was observed between ePWV and the prevalence of DKD and eGFR < 60 mL/min per 1.73 m², and a linear association between ePWV and the prevalence of UACR ≥ 30 mg/g.

Conclusion

ePWV is independently positively correlated with the prevalence of DKD. Integrating ePWV into routine clinical evaluations enable timely interventions and personalized management approaches.