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Background <p>Takotsubo syndrome (TTS) following intracranial hemorrhage, particularly cerebellar hemorrhage is rare. The use of extracorporeal membrane oxygenation (ECMO) in such cases poses significant challenges due to the bleeding-thrombosis paradox.</p> Case presentation <p>We report a 19-year-old female with cerebellar hemorrhage and TTS who developed refractory cardiogenic shock. Despite maximal pharmacologic support, anticoagulation-free venoarterial ECMO (VA-ECMO) was initiated due to the high risk of intracranial bleeding. ECMO stabilized hemodynamics; however, left femoral artery thrombosis occurred postdecannulation. Multidisciplinary collaboration prioritized cerebral protection, delaying thrombectomy until neurological stabilization. The patient regained consciousness and underwent successful delayed intervention.</p> Conclusion <p>This first reported case demonstrates the feasibility of anticoagulation-free VA-ECMO in patients with cerebellar hemorrhage with TTS. Multidisciplinary decision-making and staged management are critical for balancing thrombosis and hemorrhage risks.</p>

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Balancing thrombosis and hemorrhage: anticoagulation-free VA-ECMO with a multidisciplinary strategy for cerebellar hemorrhage complicated by takotsubo syndrome

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月29日

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  • Xianli Chen,
  • Yalan Qin,
  • Wenqi Huang,
  • Youhua Wang

摘要

Background

Takotsubo syndrome (TTS) following intracranial hemorrhage, particularly cerebellar hemorrhage is rare. The use of extracorporeal membrane oxygenation (ECMO) in such cases poses significant challenges due to the bleeding-thrombosis paradox.

Case presentation

We report a 19-year-old female with cerebellar hemorrhage and TTS who developed refractory cardiogenic shock. Despite maximal pharmacologic support, anticoagulation-free venoarterial ECMO (VA-ECMO) was initiated due to the high risk of intracranial bleeding. ECMO stabilized hemodynamics; however, left femoral artery thrombosis occurred postdecannulation. Multidisciplinary collaboration prioritized cerebral protection, delaying thrombectomy until neurological stabilization. The patient regained consciousness and underwent successful delayed intervention.

Conclusion

This first reported case demonstrates the feasibility of anticoagulation-free VA-ECMO in patients with cerebellar hemorrhage with TTS. Multidisciplinary decision-making and staged management are critical for balancing thrombosis and hemorrhage risks.