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Background <p>We aimed to determine whether preoperative chewing gum is non-inferior to Chlorhexidine (CHX) mouthwash in reducing halitosis in patients undergoing elective general anesthesia with endotracheal intubation.</p> Methods <p>We conducted a randomized, single-blind, non-inferiority controlled trial involving patients undergoing surgery requiring endotracheal intubation for ≤ 3&#xa0;h. Participants were randomly assigned to either the CHX mouthwash group (Group M) or the chewing gum group (Group N). Thirty minutes before general anesthesia, patients in Group M rinsed their mouths with 10&#xa0;ml of CHX mouthwash, while those in Group N chewed Trident mint gum. The primary outcome was the incidence of halitosis in both groups, assessed before endotracheal intubation and at extubation.</p> Results <p>A total of 733 patients were included, with 365 patients in Group M and 368 patients in Group N. The incidence of halitosis in both groups was significantly reduced compared to baseline. Before extubation, the improvement in halitosis was greater in Group N than in Group M (<i>P</i> &lt; 0.05). After extubation, the improvement in halitosis in Group N was non-inferior to that in Group M (<i>Z</i> = 1.96, 95% <i>CI</i>: -0.0898 to 0.0944, <i>p</i> = 0.0023).</p> Conclusions <p>In patients undergoing elective general anesthesia with endotracheal intubation, chewing gum was found to be non-inferior to CHX mouthwash in improving postoperative halitosis.</p> Trial registration <p>Chictr.org.cn ChiCTR2400082035 (date of registration: 19/03/2024).</p>

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Chewing gum on postoperative oral Malodor in patients undergoing general anesthesia: a randomized non-inferiority trial

  • 期刊论文

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  • 发表日期：

    2025年5月21日

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  • Baohua Zhang,
  • Yang Han,
  • Huan He,
  • Li Jin,
  • Lidong Zhang

摘要

Background

We aimed to determine whether preoperative chewing gum is non-inferior to Chlorhexidine (CHX) mouthwash in reducing halitosis in patients undergoing elective general anesthesia with endotracheal intubation.

Methods

We conducted a randomized, single-blind, non-inferiority controlled trial involving patients undergoing surgery requiring endotracheal intubation for ≤ 3 h. Participants were randomly assigned to either the CHX mouthwash group (Group M) or the chewing gum group (Group N). Thirty minutes before general anesthesia, patients in Group M rinsed their mouths with 10 ml of CHX mouthwash, while those in Group N chewed Trident mint gum. The primary outcome was the incidence of halitosis in both groups, assessed before endotracheal intubation and at extubation.

Results

A total of 733 patients were included, with 365 patients in Group M and 368 patients in Group N. The incidence of halitosis in both groups was significantly reduced compared to baseline. Before extubation, the improvement in halitosis was greater in Group N than in Group M (P < 0.05). After extubation, the improvement in halitosis in Group N was non-inferior to that in Group M (Z = 1.96, 95% CI: -0.0898 to 0.0944, p = 0.0023).

Conclusions

In patients undergoing elective general anesthesia with endotracheal intubation, chewing gum was found to be non-inferior to CHX mouthwash in improving postoperative halitosis.

Trial registration

Chictr.org.cn ChiCTR2400082035 (date of registration: 19/03/2024).