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Background <p><i>Paeonia lactiflora</i> Pall. is a traditional medicinal plant widely used in East Asia, particularly for its roots, which are processed into various herbal remedies. With the advancement of omics technologies, significant genomic, transcriptomic, proteomic, and metabolomic data related to <i>P. lactiflora</i> have been generated. To facilitate the utilization of this wealth of information for research and applications, a multi-omics database specific to <i>P. lactiflora</i> was developed.</p> Results <p>This comprehensive multi-omics database includes genomic, transcriptomic, and proteomic datasets, as well as chemical compound profiles identified in various tissues and growth stages. The database also features data on key biosynthetic pathways, including those associated with monoterpenoid glycosides such as paeoniflorin, and provides tools for analyzing protein structures and interactions. Additionally, it summarizes <i>P. lactiflora</i>’s major active compounds, and highlights reported pharmacological effects. The database is organized into key functional modules: Home, Genome, Transcriptome, Proteome, Tools, Biosynthetic Pathways, Chemical Compounds, and Publications. Notably, the “Tools” module supports sequence alignment, pathway enrichment analysis (including Kyoto Encyclopedia of Genes and Genomes, KEGG), protein structure prediction, and primer design.</p> Conclusions <p>The multi-omics database (URL: <a href="http://210.22.121.250:8888/cosd/home/indexPage">http://210.22.121.250:8888/cosd/home/indexPage</a>) of <i>P. lactiflora</i> integrates extensive molecular and chemical data, providing a robust platform for researchers. It serves as a valuable resource for advancing studies on the cultivation, breeding, and molecular pharmacognosy of <i>P. lactiflora</i> and supports the development of its medicinal applications.</p>

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Construction of a Multi-Omics database for Paeonia lactiflora: A resource for comprehensive data integration and analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月9日

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  • Zongran Lu,
  • Ling Huang,
  • Somnuk Bunsupa,
  • Hamizah Shahirah Hamezah,
  • Xiaohui Tong,
  • Chuanshan Jin,
  • Jinmei Ou,
  • Rongchun Han

摘要

Background

Paeonia lactiflora Pall. is a traditional medicinal plant widely used in East Asia, particularly for its roots, which are processed into various herbal remedies. With the advancement of omics technologies, significant genomic, transcriptomic, proteomic, and metabolomic data related to P. lactiflora have been generated. To facilitate the utilization of this wealth of information for research and applications, a multi-omics database specific to P. lactiflora was developed.

Results

This comprehensive multi-omics database includes genomic, transcriptomic, and proteomic datasets, as well as chemical compound profiles identified in various tissues and growth stages. The database also features data on key biosynthetic pathways, including those associated with monoterpenoid glycosides such as paeoniflorin, and provides tools for analyzing protein structures and interactions. Additionally, it summarizes P. lactiflora’s major active compounds, and highlights reported pharmacological effects. The database is organized into key functional modules: Home, Genome, Transcriptome, Proteome, Tools, Biosynthetic Pathways, Chemical Compounds, and Publications. Notably, the “Tools” module supports sequence alignment, pathway enrichment analysis (including Kyoto Encyclopedia of Genes and Genomes, KEGG), protein structure prediction, and primer design.

Conclusions

The multi-omics database (URL: http://210.22.121.250:8888/cosd/home/indexPage) of P. lactiflora integrates extensive molecular and chemical data, providing a robust platform for researchers. It serves as a valuable resource for advancing studies on the cultivation, breeding, and molecular pharmacognosy of P. lactiflora and supports the development of its medicinal applications.