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Objective <p>To analyze the risk factors for carbapenem-resistant <i>Klebsiella pneumoniae</i> bloodstream infection (CRKP-BSI) in children. </p> Methods <p>A total of 235 pediatric patients with <i>Klebsiella pneumoniae</i> bloodstream infection (KPN-BSI) admitted to our hospital from January 2015 to December 2025 were collected. According to the CLSI criteria, infections in which carbapenem- resistant <i>Klebsiella pneumoniae</i> was isolated from blood culture were defined as CRKP-BSI (<i>n</i>=110), and those in which carbapenem-susceptible <i>Klebsiella pneumoniae</i> was isolated were defined as CSKP-BSI (<i>n</i>=125). We compared clinical profiles of the two groups with the Mann-Whitney U test and chi-square test, and binary logistic regression was used to identify independent risk factors for CRKP-BSI. </p> Results <p>Children with CRKP-BSI were mainly distributed in the Premature Infant Department (49 cases, 44.60 %) and intensive care unit (36 cases, 32.70 %). Analysis of clinical characteristics showed that patient age, underlying diseases, antibiotic use duration ≥ 14 days, mechanical ventilation, surgical procedures during hospitalization, and hospital stay &gt; 5 days were significantly associated with CRKP-BSI (all <i>P</i> &lt; 0.05). Binary logistic regression multivariate analysis demonstrated that the mechanical ventilation (<i>β</i> = 2.896, OR = 18.106), surgical procedures during hospitalization (<i>β</i> = 1.116, <i>OR</i> = 3.052), and hospital stay &gt; 5 days (<i>β</i> = 0.957, OR = 2.603) were independently associated with CRKP-BSI. </p> Conclusion <p>It is concluded that mechanical ventilation, surgical interventions and prolonged hospitalization independently contribute to the development of CRKP-BSI in children. Enhanced monitoring and precise infection control strategies are required for vulnerable children to prevent CRKP-BSI.</p>

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Analysis of risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infections in children: a case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • Jing Jia,
  • Hailing Shi,
  • Panpan Fang,
  • Juanjuan Zhou,
  • Lu Xu,
  • Kaijie Gao,
  • Haizhen Xie,
  • Bing Yang,
  • Mingfa Guo

摘要

Objective

To analyze the risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in children.

Methods

A total of 235 pediatric patients with Klebsiella pneumoniae bloodstream infection (KPN-BSI) admitted to our hospital from January 2015 to December 2025 were collected. According to the CLSI criteria, infections in which carbapenem- resistant Klebsiella pneumoniae was isolated from blood culture were defined as CRKP-BSI (n=110), and those in which carbapenem-susceptible Klebsiella pneumoniae was isolated were defined as CSKP-BSI (n=125). We compared clinical profiles of the two groups with the Mann-Whitney U test and chi-square test, and binary logistic regression was used to identify independent risk factors for CRKP-BSI.

Results

Children with CRKP-BSI were mainly distributed in the Premature Infant Department (49 cases, 44.60 %) and intensive care unit (36 cases, 32.70 %). Analysis of clinical characteristics showed that patient age, underlying diseases, antibiotic use duration ≥ 14 days, mechanical ventilation, surgical procedures during hospitalization, and hospital stay > 5 days were significantly associated with CRKP-BSI (all P < 0.05). Binary logistic regression multivariate analysis demonstrated that the mechanical ventilation (β = 2.896, OR = 18.106), surgical procedures during hospitalization (β = 1.116, OR = 3.052), and hospital stay > 5 days (β = 0.957, OR = 2.603) were independently associated with CRKP-BSI.

Conclusion

It is concluded that mechanical ventilation, surgical interventions and prolonged hospitalization independently contribute to the development of CRKP-BSI in children. Enhanced monitoring and precise infection control strategies are required for vulnerable children to prevent CRKP-BSI.