Scholarlink

<p>Lead (Pb) toxicity is a global health concern that primarily affects the liver. This study explored the protective effects of lactobacilli against Pb(II)-induced hepatotoxicity in mice. Three strains of lactobacilli—<i>Lacticaseibacillus paracasei</i> GMNL-32, <i>Limosilactobacillus fermentum</i> GMNL-93, and <i>Lacticaseibacillus casei</i> GMNL-277—were evaluated for Pb adsorption and antioxidant activity. In a chronic Pb(II) exposure mouse model, GMNL-93 and GMNL-277 more effectively mitigated Pb(II)-associated liver damage, and upregulated RNA expression of gut function-associated proteins (e.g., <i>Cldn3</i>, <i>Cldn5</i>, and <i>Muc5</i>). Microbiome and functional pathway analyses suggested strain-specific modes of action: GMNL-93 was associated with shifts in microbial composition and enrichment of pathways linked to redox balance and bile acid metabolism, whereas GMNL-277 was linked to enhanced thiamine-related metabolism; GMNL-32 showed comparatively limited protective. Overall, lactobacilli are promising candidates for reducing lead toxicity through directly interaction and microbiome-dependent host protection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月17日

查看全文
  • Yu‑Cheng Chin,
  • Chih-Chia Huang,
  • I-Ling Hsu,
  • Wan-Hua Tsai,
  • Chia-Hsuan Chou,
  • Yi‑Ting Fang,
  • Jian‑Jia Su,
  • Yao-Tsung Yeh,
  • Hui-Yun Tsai,
  • Cheng-Hsieh Huang,
  • Szu-Wei Huang

摘要

Lead (Pb) toxicity is a global health concern that primarily affects the liver. This study explored the protective effects of lactobacilli against Pb(II)-induced hepatotoxicity in mice. Three strains of lactobacilli—Lacticaseibacillus paracasei GMNL-32, Limosilactobacillus fermentum GMNL-93, and Lacticaseibacillus casei GMNL-277—were evaluated for Pb adsorption and antioxidant activity. In a chronic Pb(II) exposure mouse model, GMNL-93 and GMNL-277 more effectively mitigated Pb(II)-associated liver damage, and upregulated RNA expression of gut function-associated proteins (e.g., Cldn3, Cldn5, and Muc5). Microbiome and functional pathway analyses suggested strain-specific modes of action: GMNL-93 was associated with shifts in microbial composition and enrichment of pathways linked to redox balance and bile acid metabolism, whereas GMNL-277 was linked to enhanced thiamine-related metabolism; GMNL-32 showed comparatively limited protective. Overall, lactobacilli are promising candidates for reducing lead toxicity through directly interaction and microbiome-dependent host protection.