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<p>Ulcerative colitis (UC) is an intestinal disease caused by multiple factors that severely affects the health of humans and animals. In this study, a DSS-induced mouse colitis model was utilized to investigate the ability of daucosterol (DAU) to alleviate colitis and its underlying mechanism of action. The experimental results showed that DAU could alleviate the clinical symptoms of colitis in mice, reduce the expression of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) in mouse serum, and modulate the gut microbiota to alleviate DSS-induced colitis in mice. In conclusion, DAU has great potential in the prevention of colitis.</p>

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Therapeutic effect of daucosterol on DSS-induced colitis in mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月4日

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  • Jing Liang,
  • Huihui Yang,
  • Kelin Chen,
  • Jiahao Cai,
  • Yuling Wang,
  • Yanhong Yong

摘要

Ulcerative colitis (UC) is an intestinal disease caused by multiple factors that severely affects the health of humans and animals. In this study, a DSS-induced mouse colitis model was utilized to investigate the ability of daucosterol (DAU) to alleviate colitis and its underlying mechanism of action. The experimental results showed that DAU could alleviate the clinical symptoms of colitis in mice, reduce the expression of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) in mouse serum, and modulate the gut microbiota to alleviate DSS-induced colitis in mice. In conclusion, DAU has great potential in the prevention of colitis.