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Background <p>This study aims to investigate the gut microbiome alterations in IgG4-related ophthalmic disease (IgG4-ROD) and explore the potential roles of serum IgE and IgG4 in this disease.</p> Methods <p>In this prospective study, we recruited a total of 34 participants, including 17 IgG4-ROD patients and 17 healthy controls (HC) from Beijing Tongren Hospital. Fecal and blood samples were collected and analyzed, including 16&#xa0;S rRNA gene sequencing of fecal samples. We assessed alpha and beta diversity to identify microbial variations among IgG4-ROD and HC, IgG4+ and IgG4-, IgE + and IgE-, and hormone-treated and untreated groups. Correlation analyses between cytokines and microbial profiles were conducted to uncover novel insights into the pathogenesis of IgG4-ROD.</p> Results <p>Significant differences in microbial composition were observed among subgroups. Patients with IgG4-ROD showed increases in Proteobacteria, <i>Parvimonas</i>, <i>Novosphingobium</i>, <i>Shigella</i>, and <i>Allobaculum</i>, along with decreased levels of <i>Faecalibacterium</i>, <i>Barnesiella</i>, and <i>Weissella</i>. The IgE + group exhibited an elevated abundance of Enterobacteriaceae, with several microbial changes overlapping between IgG4-ROD and IgE + individuals. <i>Sphingomonas</i> and Peptostreptococcaceae were more prevalent in the IgG4 + group, while <i>Adlercreutzia</i> and Acidimicrobiales were abundant in the IgG4- group. Furthermore, Ruminococcaceae were enriched in the HC and IgG4- groups. <i>Pelomonas and Escherichia</i> were increased in IgG4-ROD patients treated with glucocorticosteroids. Additionally, significant correlations were identified between several microbial taxa and serum cytokines such as IL-1β, IL-2, IFN-α, C3, and IgG4.</p> Conclusion <p>The findings indicate gut dysbiosis in IgG4-ROD and suggest influential roles for serum IgE and IgG4, enhancing our understanding of microbial-clinical interactions in this disease.</p>

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Gut microbiome alterations in IgG4-related ophthalmic disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月21日

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  • Tingting Ren,
  • Jing Li,
  • Rui Liu,
  • Nan Wang,
  • Qihan Guo,
  • Liangyuan Xu,
  • Haihan Yan,
  • Yufei Zhang,
  • Jianmin Ma

摘要

Background

This study aims to investigate the gut microbiome alterations in IgG4-related ophthalmic disease (IgG4-ROD) and explore the potential roles of serum IgE and IgG4 in this disease.

Methods

In this prospective study, we recruited a total of 34 participants, including 17 IgG4-ROD patients and 17 healthy controls (HC) from Beijing Tongren Hospital. Fecal and blood samples were collected and analyzed, including 16 S rRNA gene sequencing of fecal samples. We assessed alpha and beta diversity to identify microbial variations among IgG4-ROD and HC, IgG4+ and IgG4-, IgE + and IgE-, and hormone-treated and untreated groups. Correlation analyses between cytokines and microbial profiles were conducted to uncover novel insights into the pathogenesis of IgG4-ROD.

Results

Significant differences in microbial composition were observed among subgroups. Patients with IgG4-ROD showed increases in Proteobacteria, Parvimonas, Novosphingobium, Shigella, and Allobaculum, along with decreased levels of Faecalibacterium, Barnesiella, and Weissella. The IgE + group exhibited an elevated abundance of Enterobacteriaceae, with several microbial changes overlapping between IgG4-ROD and IgE + individuals. Sphingomonas and Peptostreptococcaceae were more prevalent in the IgG4 + group, while Adlercreutzia and Acidimicrobiales were abundant in the IgG4- group. Furthermore, Ruminococcaceae were enriched in the HC and IgG4- groups. Pelomonas and Escherichia were increased in IgG4-ROD patients treated with glucocorticosteroids. Additionally, significant correlations were identified between several microbial taxa and serum cytokines such as IL-1β, IL-2, IFN-α, C3, and IgG4.

Conclusion

The findings indicate gut dysbiosis in IgG4-ROD and suggest influential roles for serum IgE and IgG4, enhancing our understanding of microbial-clinical interactions in this disease.