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Background <p>Psoriasis, an inflammatory autoimmune disease, arises from intricate interactions between the immune system and epithelium. Recent reports have suggested new roles for gamma delta (γδ) T-cells in addition to immune surveillance, however, it remains to be determined whether the mechanisms identified in psoriasis murine models have a similar role in humans. The aim of the present study was to investigate the relationship between IL-17&#xa0;A mRNA expression levels and γδ T-cell frequency in human psoriatic lesions, and to clarify the potential role of γδ T-cells in psoriasis pathogenesis.</p> Methods <p>The study involved 20 patients diagnosed with psoriasis and 16 control subjects. Expression of the IL-17&#xa0;A gene was measured in formalin-fixed paraffin-embedded (FFPE) tissues by RT-PCR method. TCRγδ<sup>+</sup> immunofluorescence staining was performed to measure the distribution of γδ T-cells in the same samples.</p> Results <p>In psoriatic lesion biopsies, TCRγδ<sup>+</sup> T-cell percentage was found higher than the control samples. Additionally, psoriasis patients exhibited elevated levels of IL-17&#xa0;A gene expression. In addition, this study showed a weak negative correlation between the proportion of γδ T-cells and IL-17&#xa0;A mRNA expression in psoriatic skin samples.</p> Conclusion <p>A weak negative correlation between IL-17&#xa0;A mRNA levels and γδ T-cell presence in human psoriasis lesions highlighting the novel effector functions of these cells in psoriasis pathogenesis.</p>

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IL-17 A expression negatively correlates with γδ T-Cell density in human psoriasis lesions: a novel implication for disease pathogenesis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月17日

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  • Kubra Sevgin,
  • Seyma Ozkanli,
  • Gulam Hekimoglu,
  • Gamze Yesilay,
  • Nurullah Yucel,
  • Halime Tuba Canbaz,
  • Muzaffer Seker

摘要

Background

Psoriasis, an inflammatory autoimmune disease, arises from intricate interactions between the immune system and epithelium. Recent reports have suggested new roles for gamma delta (γδ) T-cells in addition to immune surveillance, however, it remains to be determined whether the mechanisms identified in psoriasis murine models have a similar role in humans. The aim of the present study was to investigate the relationship between IL-17 A mRNA expression levels and γδ T-cell frequency in human psoriatic lesions, and to clarify the potential role of γδ T-cells in psoriasis pathogenesis.

Methods

The study involved 20 patients diagnosed with psoriasis and 16 control subjects. Expression of the IL-17 A gene was measured in formalin-fixed paraffin-embedded (FFPE) tissues by RT-PCR method. TCRγδ+ immunofluorescence staining was performed to measure the distribution of γδ T-cells in the same samples.

Results

In psoriatic lesion biopsies, TCRγδ+ T-cell percentage was found higher than the control samples. Additionally, psoriasis patients exhibited elevated levels of IL-17 A gene expression. In addition, this study showed a weak negative correlation between the proportion of γδ T-cells and IL-17 A mRNA expression in psoriatic skin samples.

Conclusion

A weak negative correlation between IL-17 A mRNA levels and γδ T-cell presence in human psoriasis lesions highlighting the novel effector functions of these cells in psoriasis pathogenesis.