Scholarlink

Background <p>A-to-I RNA editing expands proteomic diversity and may contribute to caste-specific phenotypic plasticity in eusocial insects. However, the quantity-accuracy trade-off in editing detection usually hinders comprehensive characterization of the RNA editome.</p> Materials and methods <p>To overcome the quantity-accuracy trade-off, we first perform de novo identification of the neuronal A-to-I editome of the red imported fire ant <i>Solenopsis invicta</i>, and then apply an orthology-based strategy to project candidate editing sites to another ant species <i>Acromyrmex echinatior</i>.</p> Results <p>We obtain nearly 3000 editing sites in <i>S. invicta</i>, including 91 nonsynonymous (recoding) sites enriched in neuronal functions such as synaptic transmission, ion channels, and circadian rhythms. The orthology-based strategy substantially expands the previously known recoding repertoire in the leaf-cutting ant <i>A. echinatior</i>, reveals many previously missed recoding sites and edited genes, and uncovers additional caste-specific recoding events between gynes and workers, highlighting conserved, potentially functional editing targets across ant evolution. Representative recoding sites are validated by Sanger sequencing.</p> Conclusion <p>Our work expands ant RNA editome resources and identifies conserved recoding candidates that may facilitate future studies of eusocial caste diversification, neuronal function, and phenotypic plasticity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The neuronal A-to-I RNA editome of Solenopsis invicta expands conserved recoding repertoire between two ant species

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月17日

查看全文
  • Jiyao Liu,
  • Ling Ma,
  • Qiuhua Xie,
  • Wanzhi Cai,
  • Hu Li,
  • Fenghao Liu,
  • Youming Hou,
  • Lu Peng,
  • Yuange Duan

摘要

Background

A-to-I RNA editing expands proteomic diversity and may contribute to caste-specific phenotypic plasticity in eusocial insects. However, the quantity-accuracy trade-off in editing detection usually hinders comprehensive characterization of the RNA editome.

Materials and methods

To overcome the quantity-accuracy trade-off, we first perform de novo identification of the neuronal A-to-I editome of the red imported fire ant Solenopsis invicta, and then apply an orthology-based strategy to project candidate editing sites to another ant species Acromyrmex echinatior.

Results

We obtain nearly 3000 editing sites in S. invicta, including 91 nonsynonymous (recoding) sites enriched in neuronal functions such as synaptic transmission, ion channels, and circadian rhythms. The orthology-based strategy substantially expands the previously known recoding repertoire in the leaf-cutting ant A. echinatior, reveals many previously missed recoding sites and edited genes, and uncovers additional caste-specific recoding events between gynes and workers, highlighting conserved, potentially functional editing targets across ant evolution. Representative recoding sites are validated by Sanger sequencing.

Conclusion

Our work expands ant RNA editome resources and identifies conserved recoding candidates that may facilitate future studies of eusocial caste diversification, neuronal function, and phenotypic plasticity.