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<p>We present the Japan Omics Browser (JOB), which enables integrative analysis of human omics at different layers. JOB offers visualization of per-variant regulatory effects in the human blood at mRNA and protein level distinctively, quantified from statistical fine-mapping of mRNA-expression quantitative loci (eQTL) and protein QTLs (pQTLs) in 1,405 Japanese, together with fine-mapping results of 94 complex traits in UK Biobank. In addition, JOB shows per-tissue regulatory effect prediction score (EMS), trained via multi-task learning. Furthermore, validation scores from Massively Parallel Reporter Assay (MPRA) in two cell types are available for over 10,000 variants. JOB is publicly available at <a href="https://japan-omics.jp/">https://japan-omics.jp/</a>.</p>

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JOB: Japan Omics Browser provides integrative visualization of multi-omics data

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月7日

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  • Yugo Takahashi,
  • Qingbo S. Wang,
  • Takanori Hasegawa,
  • Ho Namkoong,
  • Fumitaka Inoue,
  • Koichi Fukunaga,
  • Seiya Imoto,
  • Satoru Miyano,
  • Yukinori Okada

摘要

We present the Japan Omics Browser (JOB), which enables integrative analysis of human omics at different layers. JOB offers visualization of per-variant regulatory effects in the human blood at mRNA and protein level distinctively, quantified from statistical fine-mapping of mRNA-expression quantitative loci (eQTL) and protein QTLs (pQTLs) in 1,405 Japanese, together with fine-mapping results of 94 complex traits in UK Biobank. In addition, JOB shows per-tissue regulatory effect prediction score (EMS), trained via multi-task learning. Furthermore, validation scores from Massively Parallel Reporter Assay (MPRA) in two cell types are available for over 10,000 variants. JOB is publicly available at https://japan-omics.jp/.