Scholarlink

<p>The tumor necrosis factor receptor superfamily (TNFRSF) plays a vital role in eliciting immune responses against infections. The tree shrew, closely related to primates, is often utilized in human disease models. Here, we analyzed TNFRSF members from 11 different animal species, including the Chinese tree shrew, and identified 24 tree shrew TNFRSF (tTNFRSF) genes, which were grouped into seven subcategories with similar motifs, sequences, and gene structures. As expected, the multi-species collinearity analysis revealed that tTNFRSF genome bears a greater resemblance to humans than to mice. Transcriptome data from 28 samples across ten organ types showed high TNFRSF expression predominantly in immune organs. It was seen that TNFRSF13C co-expresses consistently with the B cell surface marker CD79A, which is consistent with its characteristics in humans. The tissue distribution and co-expression were confirmed via RT-qPCR and immunofluorescence. Evaluation of transcriptome data from 70 samples infected with six types of viruses showed that most TNFRSF genes were upregulated in tree shrew post-viral infection. TNFRSF exerts antiviral function most probably through the activation of the NF-κB pathway, subsequently causing apoptosis of infected cells. Our findings provide evolutionary and functional insights into tTNFRSF, indicating its potential utility in human viral infection models.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Identification and characterization of the tumor necrosis factor receptor superfamily in the Chinese tree shrew (Tupaia belangeri chinensis)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月4日

查看全文
  • Zongjian Huang,
  • Nan Shi,
  • Zhenqiu Luo,
  • Fangfang Chen,
  • Xunwei Feng,
  • Yongjing Lai,
  • Jian Li,
  • Xiang Yi,
  • Wei Xia,
  • Anzhou Tang

摘要

The tumor necrosis factor receptor superfamily (TNFRSF) plays a vital role in eliciting immune responses against infections. The tree shrew, closely related to primates, is often utilized in human disease models. Here, we analyzed TNFRSF members from 11 different animal species, including the Chinese tree shrew, and identified 24 tree shrew TNFRSF (tTNFRSF) genes, which were grouped into seven subcategories with similar motifs, sequences, and gene structures. As expected, the multi-species collinearity analysis revealed that tTNFRSF genome bears a greater resemblance to humans than to mice. Transcriptome data from 28 samples across ten organ types showed high TNFRSF expression predominantly in immune organs. It was seen that TNFRSF13C co-expresses consistently with the B cell surface marker CD79A, which is consistent with its characteristics in humans. The tissue distribution and co-expression were confirmed via RT-qPCR and immunofluorescence. Evaluation of transcriptome data from 70 samples infected with six types of viruses showed that most TNFRSF genes were upregulated in tree shrew post-viral infection. TNFRSF exerts antiviral function most probably through the activation of the NF-κB pathway, subsequently causing apoptosis of infected cells. Our findings provide evolutionary and functional insights into tTNFRSF, indicating its potential utility in human viral infection models.